Nuclear Magnetic Resonance Spectroscopy finished projects include:
1. NMR investigations of the local structure and dynamics in solids and solutions, IUT23-7
Project duration: 01.01.14 – 31.12.19
Principal Investigator: Dr. Ivo Heinmaa
This research topic focuses on the development of NMR instrumentation and on implementing NMR methods to materials science, chemistry and biology. Proposed applications cover solid state and solution NMR. The main topics of solid state NMR research are: investigation of spin structure in quantum magnets, study of charge localization in high temperature superconductors, local structure and vacancy dynamics in fuel cell components, structure determination of solid organic compounds at natural abundance of 13C by using 2D NMR correlation spectroscopy and quantum chemical calculations. Applications of solution NMR cover the idenfication of synthesis products, the study of molecular interactions in solution and metabolomics analysis. An essential part of the work is improving NMR technology: the cryoMAS probe will allow new applications at low temperatures and the probe with high 13C sensitivity allows to study the structure of organic compounds at natural abundance of NMR active isotopes.
Link to ETIS here.
2. Profiling phosphometabolomic pathways in colorectal cancer by 18O isotope effect assisted 31P NMR spectroscopy , MOBTP51
Project duration: 01.09.17 – 31.08.19
Principal Investigator: Dr. Indrek Reile
Cancer is one of the leading causes of mortality and an increasing burden on healthcare systems worldwide. It is an incredibly complex and heterogeneous disease that may be caused by a variety of triggers, yet most cancers share similarities in the way their energy metabolism is changed in comparison to healthy tissue. Despite decades of research, our understanding of these changes, and of cancer metabolism in general, is incomplete. Such lack of insight into cancer and its energy production is hindering the development of new therapies and optimal treatments. Herein, we will focus on colorectal cancer, the 3rd most common cancer, to compile a comprehensive qualitative and quantitative profile of its energy production processes. This information will allow to evaluate tumor aggressiveness and to identify new molecular targets for therapy. The project relies on 1H NMR, 31P NMR and 18O assisted 31P NMR and will develop a new diagnostic tool to support cancer research.
Link to ETIS here.