Publications

2025

Marju Puurand, Rutt Taba, Kersti Tepp, Anton Terasmaa, Tuuli Käämbre Vähkkasvajate paindlikust ainevahetusest võib saada nende Achilleuse kand. ERR Novaator, 26.06.2025
Moreno-Sanchez, Rafael; Vargas-Navarro, Jorge Luis; Padilla-Flores, Joaquín Alberto; Robledo-Cadena, Diana Xochiquetzal; Granados-Rivas, Juan Carlos; Taba, Rutt; Terasmaa, Anton; Auditano, Giuseppe Leonardo; Kaambre, Tuuli; Rodríguez Enríquez, Sara (2025). Energy Metabolism Behavior and Response to Microenvironmental Factors of the Experimental Cancer Cell Models Differ From That of Actual Human Tumors. Mini-Reviews in Medicinal Chemistry, 25 (4), 319−339. DOI: 10.2174/0113895575322436240924101642.
Taba, Rutt; Põlluaed, Marie; Tein, Karin; Puurand, Marju; Käämbre, Tuuli; Terasmaa, Anton (2025). Effect of Media Composition and Oxygen Tension on Cellular Stress Response and Nrf2 Activation in HepG2ARE Cells. Antioxidants, 14 (2), 137. DOI: 10.3390/antiox14020137.
Reinsalu, Leenu; Miller, Sten; Auditano, Giuseppe Leonardo; Puurand, Marju; Moreno-Sanchez, Rafael; Saavedra, Emma; Valvere, Vahur; Käämbre, Tuuli (2025). Energy Metabolism Profiling of Human Colorectal Tumours. Journal of Cellular and Molecular Medicine, 29 (5), e70462. DOI: 10.1111/jcmm.70462.
Puurand, Marju; Llorente, Alicia; Line, Aija; Kaambre, Tuuli (2025). Exercise-induced extracellular vesicles in reprogramming energy metabolism in cancer. Frontiers in Oncology, 14, ARTN 1480074. DOI: 10.3389/fonc.2024.1480074.
Tepp, Kersti; Auditano, Giuseppe Leonardo; Puurand, Marju; Kaambre, Tuuli (2025). Reliability of Pesticide Toxicity Evaluation: Effects of Pesticides on Cellular Respiration under Conventional Versus Physiological Growth Conditions. Environmental Toxicology and Pharmacology, DOI: 10.1016/j.etap.2025.104675. 104675.

2024

Sarsenova, Meruert; Lawarde, Ankita; Pathare, Amruta D. S.; Saare, Merli; Modhukur, Vijayachitra; Soplepmann, Pille; Terasmaa, Anton; Käämbre, Tuuli; Gemzell Danielsson, Kristina; Lalitkumar, Parameswaran Grace Luther; Salumets, Andres; Peters, Maire (2024). Endometriotic lesions exhibit distinct metabolic signature compared to paired eutopic endometrium at the single-cell level. In: Endometriotic lesions exhibit distinct metabolic signature compared to paired eutopic endometrium at the single-cell level
BioRxiv: Cold Spring Harbor Laboratory. DOI: 10.1101/2024.02.27.580606.
Aid, Jekaterina; Tanjeko, Ajime Tom; Serre, Jef; Eggelbusch, Moritz; Noort, Wendy; de Wit, Gerard M. J.; van Weeghel, Michel; Puurand, Marju; Tepp, Kersti; Gayan Ramirez, Ghislaine; Degens, Hans; Kaambre, Tuuli; Wust, Rob C. I. (2024). Smoking cessation only partially reverses cardiac metabolic and structural remodeling in mice. Acta Physiologica. DOI: 10.1111/apha.14145.
Llorente, Alicia; Brokāne, Agnese; Mlynska, Agata; Puurand, Marju; Sagini, Krizia; Folkmane, Signe; Hjorth, Marit; Martin‐Gracia, Beatriz; Romero, Silvana; Skorinkina, Diana; Čampa, Mārtiņš; Cešeiko, Rūdolfs; Romanchikova, Nadezhda; Kļaviņa, Aija; Käämbre, Tuuli; Linē, Aija (2024). From sweat to hope: The role of exercise‐induced extracellular vesicles in cancer prevention and treatment. Journal of Extracellular Vesicles, 13 (8), e12500. DOI: 10.1002/jev2.12500.
Sarsenova, Meruert; Lawarde, Ankita; Pathare, Amruta D S; Saare, Merli; Modhukur, Vijayachitra; Soplepmann, Pille; Terasmaa, Anton; Käämbre, Tuuli; Gemzell Danielsson, Kristina; Lalitkumar, Parameswaran Grace Luther; Salumets, Andres; Peters, Maire (2024). Endometriotic lesions exhibit distinct metabolic signature compared to paired eutopic endometrium at the single-cell level. Communications Biology, 7 (1), 1026. DOI: 10.1038/s42003-024-06713-5.
Rodríguez-Enríquez, S.; Robledo-Cadena, D.X.; Pacheco-Velázquez, S.C.; Vargas Navarro, J.L.; Padilla-Flores, J.A.; Kaambre, T.; Moreno-Sánchez, R. (2024). Repurposing auranofin and meclofenamic acid as energy-metabolism inhibitors and anti-cancer drugs. PLoS ONE, 19 (9), 1−22. DOI: 10.1371/journal.pone.0309331.
Robledo-Cadena, Diana Xochiquetzal; Pacheco-Velázquez, Silvia Cecilia; Vargas Navarro, Jorge Luis; Padilla-Flores, Joaquín Alberto; López-Marure, Rebeca; Pérez Torres, Israel; Kaambre, Tuuli; Moreno-Sánchez, Rafael; Rodríguez-Enríquez, Sara (2024). Synergistic celecoxib and dimethyl-celecoxib combinations block cervix cancer growth through multiple mechanisms. PLoS ONE, 19 (9), e0308233. DOI:10.1371/journal.pone.0308233.

2023

Rebane-Klemm, Egle; Reinsalu, Leenu; Puurand, Marju; Shevchuk, Igor; Bogovskaja, Jelena; Suurmaa, Kulliki; Valvere, Vahur; Moreno-Sanchez, Rafael; Kaambre, Tuuli(2023). Colorectal polyps increase the glycolytic activity. Frontiers in Oncology, 13, 1171887. DOI: 10.3389/fonc.2023.1171887.
Puurand, Marju; Tepp, Kersti; Käämbre, Tuuli (2023). Diving into cancer OXPHOS The application of metabolic control analysis to cell and tissue research. Biosystems, 105032. DOI: 10.1016/j.biosystems.2023.105032.
Auditano, Giuseppe Leonardo; Kullison, Karolin; Kaambre, Tuuli; Tepp, Kersti (2023). The Effects of Pesticides on the Bioenergetics of Intestinal Cells. International Conference EcoBalt 2023 “Chemicals & Environment”, 92. MDPI, 66. (1). DOI: 10.3390/proceedings2023092066.

2022

Tepp, Kersti; Aid-Vanakova, Jekaterina; Puurand, Marju; Timohhina, Natalja; Reinsalu, Leenu; Tein, Karin; Plaas, Mario; Shevchuk, Igor; Terasmaa, Anton; Kaambre, Tuuli; (2022). Wolframin deficiency is accompanied with metabolic inflexibility in rat striated muscles. Biochemistry and Biophysics Reports, 30, 101250. DOI: 10.1016/j.bbrep.2022.101250.
Klepinin, Aleksandr; Miller, Sten; Reile, Indrek; Puurand, Marju; Rebane-Klemm, Egle; Klepinina, Ljudmila; Vija, Heiki; Zhang, Song; Terzic, Andre; Dzeja, Petras; and Käämbre, Tuuli (2022). Stable isotope tracing uncovers reduced γ/β-ATP turnover and metabolic flux through mitochondrial-linked phosphotransfer circuits in aggressive breast cancer cells. Frontiers in Oncology, 12 (Cancer Metabolism), 892195. DOI: 10.3389/fonc.2022.892195.
Kaambre, Tuuli (2022). Editorial: Women in cancer metabolism 2021/2022. Frontiers in Oncology, 12, ARTN 1042349. DOI: 10.3389/fonc.2022.1042349.

2021

Zhang, Song; Yamada, Satsuki; Park, Sungjo; Klepinin, Aleksandr; Kaambre, Tuuli; Terzic, Andre; Dzeja, Petras (2021). Adenylate kinase AK2 isoform integral in embryo and adult heart homeostasis. Biochemical and Biophysical Research Communications, 546, 59−64. DOI:10.1016/j.bbrc.2021.01.097
Kaup, Karl Kristjan; Toom, Lauri; Truu, Laura; Miller,Sten; Puurand, Marju; Tepp, Kersti; Käämbre Tuuli; Reile, Indrek (2021). A line-broadening free real-time 31P Pure Shift NMR method for phosphometabolomic analysis. The Analyst, 146 (18), 5502−5507. DOI: 10.1039/d1an01198g.
Reinsalu, Leenu; Puurand, Marju; Chekulayev, Vladimir; Miller, Sten; Shevchuk, Igor; Tepp, Kersti; Rebane-Klemm, Egle; Timohhina, Natalja; Terasmaa, Anton; Kaambre, Tuuli (2021). Energy Metabolic Plasticity of Colorectal Cancer Cells as a Determinant of Tumor Growth and Metastasis. Frontiers in Oncology, 11, ARTN 698951. DOI: 10.3389/fonc.2021.698951.
Klepinina, Ljudmila; Klepinin, Aleksandr; Truu, Laura; Chekulayev, Vladimir; Vija, Heiki; Kuus, Kaisa; Teino, Indrek; Pook, Martin; Maimets, Toivo; Kaambre, Tuuli (2021). Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS ONE, 16 (1), ARTN e0245348. DOI:10.1371/journal.pone.0245348.

2020

Tepp, Kersti; Puurand, Marju; Timohhina, Natalja; Aid-Vanakova, Jekaterina; Reile, Indrek; Shevchuk, Igor; Chekulayev, Vladimir; Eimre, Margus; Peet, Nadežda; Kadaja, Lumme; Paju, Kalju; Kaambre, Tuuli (2020). Adaptation of mice striated muscles to wolframin deficiency: alterations in cellular bioenergetics. Biochemica et Biophysica Acta. DOI:10.1016/j.bbagen.2020.129523.
Ruiz‐Meana, Marisol; Boengler, Kerstin; Garcia‐Dorado, David; Hausenloy, Derek J.; Käämbre, Tuuli; Kararigas, Georgios; Perrino, Cinzia; Schulz, Rainer; Ytrehus, Kirsti (2020). Ageing, sex and cardioprotection. British Journal of Pharmacology. DOI: 10.1111/bph.14951
Zuurbier, Coert J; Bertrand, Luc; Beauloye, Christoph R; Andreadou, Ioanna; Ruiz Meana, Marisol; Jespersen, Nichlas R; Kula-Alwar, Duvaraka; Prag, Hiran A; Eric Botker, Hans; Dambrova, Maija; Montessuit, Christophe; Kaambre, Tuuli; Liepinsh, Edgars; Brookes, Paul S; Krieg, Thomas (2020). Cardiac metabolism as a driver and therapeutic target of myocardial infarction. Journal of Cellular and Molecular Medicine. DOI: 10.1111/jcmm.15180
Aleksandr Klepinin, Song Zhang, Ljudmila Klepinina, Egle Rebane-Klemm, Andre Terzic, Tuuli Kaambre, Petras Dzeja (2020). Adenylate kinase and metabolic signaling in cancer cells. Frontiers in Oncology, 10, 660. DOI:10.3389/fonc.2020.00660
Koit, Andre; Timohhina, Natalja; Truu, Laura; Chekulayev, Vladimir; Gudlawar, Shivakumar; Shevchuk, Igor; Lepik, Katrin; Mallo, Lea; Kutner, Riina; Valvere, Vahur; Kaambre, Tuuli (2020). Metabolic and OXPHOS Activities Quantified by Temporalex vivoAnalysis Display Patient-Specific Metabolic Vulnerabilities in Human Breast Cancers. Frontiers in Oncology, DOI:10.3389/fonc.2020.01053.
Timohhina, Natalja; Cerrato, Carmine Pasquale; Kurrikoff, Kaido; Chekulayev, Vladimir; Aid-Vanakova, Jekaterina; Puurand, Marju; Tepp, Kersti; Shevchuk, Igor; Langel, Ulo; Kaambre, Tuuli (2020). Viability and mitochondrial bioenergetic functions in human colon cancer cells are not affected by treatment with peptides mtCPP1, UPF25, mtgCPP, and mtCPP1gHO. bioRxiv, 1−20. DOI:10.1101/2020.07.03.185967
Rebane-Klemm, Egle; Truu, Laura; Reinsalu, Leenu; Puurand, Marju; Shevchuk, Igor; Chekulayev, Vladimir; Timohhina, Natalja; Tepp, Kersti; Bogovskaja, Jelena; Afanasjev, Vladimir; Suurmaa, Külliki; Valvere, Vahur; Käämbre, Tuuli (2020). Mitochondrial Respiration in KRAS and BRAF Mutated Colorectal Tumors and Polyps. Cancers, 12 (4), ARTN 815. DOI:10.3390/cancers12040815.

2019

Mado, Kati; Chekulayev, Vladimir; Shevchuk, Igor; Puurand, Marju; Tepp, Kersti; Kaambre, Tuuli (2019). On the role of tubulin, plectin, desmin and vimentin in the regulation of mitochondrial energy fluxes in muscle cells. American Journal of Physiology – Cell Physiology, 316 (5), C657−C667. DOI: 10.1152/ajpcell.00303.2018.
Puurand, Marju; Tepp, Kersti; Timohhina, Natalja; Aid, Jekaterina; Shevchuk, Igor; Chekulayev, Vladimir; Kaambre, Tuuli. (2019). Tubulin βII and βIII Isoforms as the Regulators of VDAC Channel Permeability in Health and Disease. Cells. DOI:10.3390/cells8030239.
Makrecka‐Kuka, Marina; Liepinsh, Edgars; Murray, Andrew J.; Lemieux, Hélène;
Dambrova, Maija; Tepp, Kersti; Puurand, Marju; Käämbre, Tuuli; Han, Woo Hyun; de Goede, Paul; O’Brien, Katie A.; Turan, Belma; Tuncay, Erkan; Olgar, Yusuf; Rolo, Anabela P.; Palmeira, Carlos M.; Boardman, Neoma T; Wüst, Rob CI; Larsen, Terje S (2019). Altered mitochondrial metabolism in the insulin resistant heart. Acta Physiologica. DOI: 10.1111/apha.13430.
Gnaiger, E; Aasander, Frostner, E; Abumrad, NA; Acuna-Castroviejo, D; Adams, SH; Ahn, B; Ali, SS; Alves, MG; Amati, F; Amoedo, ND; Andreadou, I; Arago, Belenguer, M; Aral, C; Arandarcikaite, O; Armand, AS; Arnould, T; Avram, VF; Bailey, DM; Bajpeyi, S; Bajzikova, M … Zvejniece, L (2019). Mitochondrial respiratory states and rates: Building blocks of mitochondrial physiology. 1−40. DOI:10.26124/mitofit:190001.v6.

2018

Puurand, Marju; Tepp, Kersti; Klepinin, Aleksandr; Klepinina, Lyudmila; Shevchuk, Igor; Kaambre, Tuuli (2018). Intracellular Energy-Transfer Networks and High Resolution Respirometry: A Convenient Approach for Studying Their Function. International Journal of Molecular Sciences, 19 (10). DOI: 10.3390/ijms19102933
Ounpuu, Lyudmila; Truu, Laura; Shevchuk, Igor; Chekulayev, Vladimir; Klepinin,
Aleksandr; Koit, Andre; Tepp, Kersti; Puurand, Marju; Rebane-Klemm, Egle;
Käämbre, Tuuli (2018). Comparative analysis of the bioenergetics of human adenocarcinoma Caco-2 cell line and postoperative tissue samples from colorectal cancer patients. Biochemistry and Cell Biology. DOI: 10.1139/bcb-2018-0076.
Klepinin, Aleksandr; Ounpuu, Lyudmila; Mado, Kati; Truu, Laura; Chekulayev,
Vladimir; Puurand, Marju; Shevchuk, Igor; Tepp, Kersti; Planken, Anu; Kaambre,
Tuuli (2018). The complexity of mitochondrial outer membrane permeability and VDAC regulation by associated proteins. Journal of Bioenergetics and Biomembranes. DOI: 10.1007/s10863-018-9765-9.
Ounpuu, Ljudmila; Klepinin, Aleksandr; Niemeister, Elen; Vija, Heiki; Kaambre,
Tuuli; (2018). The phosphotransfer network and metabolic plasticity of colon cancer cells. P7 b/12−P7 b/12.
Tepp, Kersti; Puurand, Marju; Klepinin, Aleksandr; Reile, Indrek; Kaambre, Tuuli;
(2018). Alterations in energy transfer pathways in Wfs1 deficient mice. Biochimica et Biophysica Acta (BBA) – Bioenergetics, Volume 1859, Supplement, September 2018, 1859: 20th European Bioenergetics Conference, August 25-30, 2018. Budapest, Hungary: European Bioenergetics Conference, e92.
Truu, Laura; Rebane-Klemm, E.; Shevchuk, I.; Ounpuu, L.; Koit, A.; Chekulayev, V.; Kaambre, T.; (2018). Different regulation of mitochondrial respiration in human colorectal and breast cancer clinical samples. 20th European Bioenergetics
Conference: European Bioenergetics Conference, August 25-30, 2018. Budapest,
Hungary: European Bioenergetics Conference, P7 b/15−P7 b/15.

2017

Ounpuu, Lyudmila; Klepinin, Aleksandr; Pook, Martin; Teino, Indrek; Peet, Nadezda; Paju, Kalju; Tepp, Kersti; Chekulayev, Vladimir; Shevchuk, Igor; Koks, Sulev; Maimets, Toivo; Kaambre, Tuuli (2017). 2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells. Biochimica et Biophysica Acta (BBA) – General Subjects, 1861, 2146−2154. DOI: 10.1016/j.bbagen.2017.05.020.
Koit, Andre; Timohhina, Natalja; Chekulayev, Vladimir; Valvere, Vahur; Kaambre,
Tuuli (2017). Abstract LB-268: Rate of temporal citrate efflux from malignant mitochondria predicts clinical aggressiveness in breast tumors. Cancer Research, 77: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, LB-268−LB-268. (13 Supplement). DOI: 10.1158/1538 7445.am2017-lb-268
Truu, L.; Koit, A.; Shevchuk, I.; Ounpuu, L.; Klepinin, A.; Chekulayev, V.;
Timohhina, N.; Tepp, K.; Puurand, M.; Heck, K.; Valvere, V.; Guzun, R.; Kaambre, T. (2017). Bioenergetic comparison of human colorectal and breast cancer clinical
patients. FEBS Journal, 284: 42nd FEBS Congress; Jerusalem, Israel; September 10 14, 2017. Wiley, 282−282. (Suppl. 1).
Ounpuu, L.; Klepinin, A.; Pook, M.; Teino, I.; Peet, N.; Paju, K.; Tepp, K.; Timohhina, N.; Chekulayev, V; Shevchuk, I.; Maimets, T.; Kaambre, T. (2017). Human embryonal carcinoma stem cells display distinct bioenergetic profile compared to normal embryonic stem cells. FEBS Journal, 284: 42nd FEBS Congress; Jerusalem, Israel; September 10–14, 2017. Wiley, 254−255. (Suppl. 1).
Kaambre, T.; Chekulayev, V.; Shevchuk, I.; Heck, K.; Truu, L.; Planken, A. (2017).
Alterations in Regulation of Mitochondrial Respiration and Metabolic Fluxes in
Human Colorectal Cancer and Surrounding Tissues. BIT’s 10th Annual World Cancer Congress -2017 (WCC-2017): Barcelona, Spain; 19-21, May 2017. Barcelona, Spain: 10th Annual World Cancer Congress, 100−100.
Koit, Andre; Shevchuk, Igor; Ounpuu, Lyudmila; Klepinin, Aleksandr; Chekulayev,
Vladimir; Timohhina, Natalja; Tepp, Kersti; Puurand, Marju; Truu, Laura; Heck,
Karoliina; Valvere, Vahur; Guzun, Rita; Kaambre, Tuuli (2017). Mitochondrial
Respiration in Human Colorectal and Breast Cancer Clinical Material Is Regulated Differently. Oxidative Medicine and Cellular Longevity, 2017 (1372640), 1−16. DOI: 10.1155/2017/1372640.
Tepp, K.; Puurand, M.; Timohhina, N.; Adamson, J.; Klepinin, A.; Truu, L.; Shevchuk, I.; Chekulayev, V.; Kaambre, T. (2017). Changes in the mitochondrial function and in the efficiency of energy transfer pathways during cardiomyocyte aging. Molecular and Cellular Biochemistry, 432 (1-2), 141−158. DOI: 10.1007/s11010-017-3005-1.
Bagur, Rafaela; Tanguy, Stéphane; Foriel, Sarah; Grichine, Alexei; Sanchez, Caroline; Pernet-Gallay, Karin; Kaambre, Tuuli; Kuznetsov, Andrey V; Usson, Yves; Boucher, François; Guzun, Rita (2016). The impact of cardiac ischemia /reperfusion on the mitochondria-cytoskeleton interactions. Biochimica et Biophysica Acta, 1862 (6), x1159−1171. DOI: 10.1016/j.bbadis.2016.03.009
Tepp, K.; Timohhina, N.; Puurand, M.; Klepinin,A.; Chekulayev, V.; Shevchuk,I.;
Kaambre, T. (2016). Bioenergetics of the aging heart and skeletal muscles: Modern concepts and controversies. Ageing Research Reviews, 28, 1−14. DOI: 10.1016/j.arr.2016.04.001
Ounpuu, Lyudmila; Klepinin, Aleksandr; Chekulayev, Vladimir; Shevchuk, Igor;
Timohhina, Natalja; Tepp, Kersti; Kaambre, Tuuli; (2016). On the influence of
microenvironment on bioenergetics of bowel cancer. Biochimica et Biophysica Acta
(BBA) – Bioenergetics, 1857, Supplement: EBEC 2016: 19th European Bioenergetics Conference, 02-07 July 2016 Riva del Garda, Italy. Elsevier, e112−e113. DOI: 10.1016/j.bbabio.2016.04.242
Klepinin, Aleksandr; Ounpuu, Lyudmila; Guzun, Rita; Chekulayev, Vladimir;
Timohhina, Natalja; Tepp, Kersti; Shevchuk, Igor; Schlattner, Uwe; Kaambre, Tuuli (2016). Simple oxygraphic analysis for the presence of adenylate kinase 1 and 2 in normal and tumor cells. Journal of Bioenergetics and Biomembranes, 48 (5), 531−548.
Kersti Tepp; Marju Puurand; Natalja Timohhina; Jasper Adamson; Aleksandr
Klepinin; Igor Shevchuk; Vladimir Chekulayev; Tuuli Käämbre (2016). New aspects of the bioenergetics of the aging heart — Changes in Intracellular Energetic Unit. In: Paolo Bernardi (Ed.). Biochimica et Biophysica Acta (BBA) – Bioenergetics. (e100). EBEC 2016: 19th European Bioenergetics Conference, 02-07 July 2016 Riva del Garda, Italy. Elsevier. (Supplement). DOI: 10.1016/j.bbabio.2016.04.338.

2015

Chekulayev, Vladimir; Mado, Kati; Shevchuk, Igor; Koit, Andre; Kaldma, Andrus;
Klepinin, Aleksandr; Timohhina, Natalja; Tepp, Kersti; Kandashvili, Manana; Ounpuu, Lyudmila; Heck, Karoliina; Truu, Laura; Planken, Anu; Valvere, Vahur; Kaambre, Tuuli (2015). Metabolic remodeling in human colorectal cancer and surrounding tissues: alterations in regulation of mitochondrial respiration and metabolic fluxes. Biochemistry and Biophysics Reports, 4, 111−125.
Guzun, Rita; Kaambre, Tuuli; Bagur, Rafaela; Grichine, Alexei; Usson, Yves;
Varikmaa, Minna; Anmann, Tiia; Tepp, Kersti; Timohhina, Natalja; Shevchuk, Igor; Chekulayev, Vladimir; Boucher, Francois; Dos Santos, Pierre; Schlattner, Uwe; Wallimann, Theo; Kuznetsov, Andrey; Dzeja, Petras; Aliev, Mayis; Saks, Valdur (2015). Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation. Acta Physiologica, 213 (1), 84−106. DOI: 10.1111/apha.12287

2014

Tepp, K.; Mado, K.; Varikmaa, M.; Klepinin, A.; Timohhina, N.; Shevchuk, I.;
Chekulayev, V.; Kuznetsov, A. V.; Guzun, R.; Kaambre, T. (2014). The role of tubulin in the mitochondrial metabolism and arrangement in muscle cells. Journal of Bioenergetics and Biomembranes, 46, 421−434.
Anmann, Tiia; Varikmaa, Minna; Timohhina, Natalja; Tepp, Kersti; Shevchuk, Igor, Chekulayev, Vladimir’; Saks, Valdur; Kaambre, Tuuli. (2014). Formation of highly organized intracellular structure and energy metabolism in cardiac muscle cells during postnatal development of rat heart. Biochimica et Biophysica Acta (BBA) Bioenergetics, 1837 (8), 1350−1361. DOI: 10.1016/j.bbabio.2014.03.015
Kaldma, Andrus; Klepinin, Aleksandr; Chekulayev, Vladimir; Mado, Kati; Shevchuk, Igor; Timohhina, Natalja; Tepp, Kersti; Kandashvili, Manana; Varikmaa, Minna; Koit, Andre; Planken, Margus; Heck, Karoliina; Truu, Laura; Planken, Anu; Valvere, Vahur; Rebane, Egle; Kaambre, Tuuli. (2014). An in situ study of bioenergetic properties of human colorectal cancer: The regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome. The International Journal of Biochemistry & Cell Biology, 55, 171−186. DOI: 10.1016/j.biocel.2014.09.004.
Varikmaa, Minna; Bagur, Rafaela; Käämbre, Tuuli; Grichine, Alexei; Timohhina,
Natalja; Tepp, Kersti; Shevchuk, Igor; Chekulayev, Vladimir; Metsis, Madis; Boucher, Francois; Saks, Valdur; Kuznetsov, Andrey V.; Guzun, Rita (2014). Role of mitochondria-cytoskeleton interactions in respiration regulation and mitochondrial organization in striated muscles. Biochimica et Biophysica Acta (BBA) Bioenergetics, 1837 (2), 232−245. DOI: 10.1016/j.bbabio.2013.10.011
Klepinin, Aleksandr; Chekulayev, Vladimir; Timohhina, Natalja; Shevchuk, Igor;
Tepp, Kersti; Kaldma, Andrus; Koit, Andre; Saks, Valdur; Kaambre, Tuuli (2014).
Comparative analysis of some aspects of mitochondrial metabolism in differentiated and undifferentiated neuroblastoma cells. Journal of Bioenergetics and Biomembranes, 46 (1), 17−31. DOI: 10.1007/s10863-013-9529-5
Saks, V.; Schlattner, U.;Tokarska-Schlattner, M.; Wallimann, T.; Bagur, R.; Zorman, S.; Pelosse, M.; Dos Santos, P.; Boucher, F; Kaambre, T.; Guzun, R. (2014). Systems Level Regulation of Cardiac Energy Fluxes Via Metabolic Cycles: Role of Creatine,Phosphotransfer Pathways, and AMPK Signaling. In: Aon, Miguel A.; Saks, Valdur; Schlattner, Uwe (Ed.). ” SYSTEMS BIOLOGY OF METABOLIC AND SIGNALING NETWORKS: ENERGY, MASS AND INFORMATION TRANSFER.”. (261−320). Heidelberg: Springer-Verlag Berlin. (Springer Series in Biophysics; 16). DOI: 10.1007/978-3-642-38505-6_11

2013

Andre; Kaldma, Andrus; Guzun, Rita; Valvere, Vahur; Saks, Valdur (2013). Metabolic Control Analysis of Respiration in Human Cancer Tissue. Frontiers in Physiology, 4, 1−6. DOI: 10.3389/fphys.2013.00151
Varikmaa, M.; Guzun, R.; Grichine, A.; Gonzalez-Granillo, M;, Usson, Y.: Boucher,
F.; Kaambre, T.; Saks, V. (2013). Matters of the heart in bioenergetics: mitochondrial fusion into continuous reticulum is not needed for maximal respiratory activity. Journal of Bioenergetics and Biomembranes, 45 (4), 319−331. DOI: 10.1007/s10863-012 9494-4
Käämbre, Tuuli; Koit, Andre; Ševtšuk, Igor; Tšekulajev, Vladimir; Tepp, Kersti;
Timohhina, Natalja; Bogovskaja, Jelena; Valvere, Vahur; Saks, Valdur (2013). Uusi
suundi kasvajate energiametabolismi uuringutes. Eesti Arst, 92 (5), 261−267.
Anmann, Tiia; Varikmaa, Minna; Tepp, Kersti; Timohhina, Natalja; Ševtšuk, Igor;
Tšekulajev, Vladimir; Saks, Valdur; Käämbre, Tuuli (2013). Südamerakkude
sünnijärgse arengu bioenergeetilised aspektid: struktuuri ja funktsiooni vaheliste seoste väljakujunemine. Eesti Arst, 92 (7), 372−381
Käämbre, Tuuli; Varikmaa, Minna (2013). Energia, elu ja tervis: süsteemibioloogiast, bioenergeetikast ja biomeditsiinist. Horisont, 1, 16−23.
Kuznetsov, A.V.; Guzun, R.; Boucher, F.; Bagur, R.; Käämbre, T.; Saks, V. (2012).
Mysterious Ca2+-independent muscular contraction: deja vu. Biochemical Journal, 445, 333−336. DOI: 10.1042/BJ20120439.

2012

Käämbre, T.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Timohhina, N.; Tepp, K.; Bogovskaja, J.; Kütner, R.; Valvere, V.; Saks, V. (2012). Metabolic control analysis of cellular respiration in situ in intraoperational samples of human breast cancer. Journal of Bioenergetics and Biomembranes, 44 (5), 539−558. DOI: 10.1007/s10863-012-9457-9
Guzun, R.; Gonzalez-Granillo, M.; Karu-Varikmaa, M.; Grichine, A.; Usson, Y.;
Käämbre, T.; Guerrero-Roesch, K.; Kuznetsov, A.; Schlattner, U.; Saks, V. (2012).
Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial Interactosome. Biochimica et Biophysica Acta, 1818, 1545−1554. DOI: 10.1016/j.bbamem.2011.12.034
Gonzalez-Granillo, M.; Grichine, A.; Guzun, R.; Ussov, Y.; Tepp, K.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Kuznetsov, A.V.; Grimm, M.; Saks, V.; Käämbre, T. (2012). Studies of the role of tubulin beta II isotype in regulation of mitochondrial respiration in intracellular energetic units in cardiac cells. Journal of Molecular and Cellular Cardiology, 52, 437−447. DOI: 10.1016/j.yjmcc.2011.07.027
Saks, V.; Kuznetsov, A.V.; Gonzalez-Granillo, M.; Tepp, K.; Timohhina, N.; Karu
Varikmaa, M.; Käämbre, T.; Santos, P.D.; Boucher, F.; Guzun, R. (2012). Intracellular energetic Units regulate metabolism in cardiac cells. Journal of Molecular and Cellular Cardiology, 419−436. DOI: 10.1016/j.yjmcc.2011.07.015

2011

Aliev, M., Guzun, R., Karu-Varikmaa, M., Kaambre, T., Wallimann, T., Saks, V.
(2011). Molecular system bioenergics of the heart: experimental studies of metabolic compartmentation and energy fluxes versus computer modeling. International Journal of Molecular Sciences, 12 (12), 9296−9331. DOI: 10.3390/ijms12129296
Tepp, Kersti; Shevchuk, Igor; Chekulayev, Vladimir; Timohhina, Natalja; Kuznetsov, Andrey V.; Guzun, Rita; Saks, Valdur; Käämbre, Tuuli (2011). High efficiency of energy flux controls within mitochondrial interactosome in cardiac intracellular energetic units. Biochimica et Biophysica Acta (BBA) – Bioenergetics, 1807 (12), 1549−1561. DOI: 10.1016/j.bbabio.2011.08.005.
Guzun, R.; Timohhina, N.; Tepp, K.; Gonzalez-Granillo, M.; Shevchuk, I.;
Chekulayev, V.; Kuznetsov, A.V.; Käämbre, T.; Saks, V.A. (2011). Systems
bioenergetics of creatine kinase networks: physiological roles of creatine and phosphocreatine in regulation of cardiac cell function. Amino Acids, 40, 1333−1348.
Guzun, Rita; Karu-Varikmaa, Minna; Gonzalez-Granillo, Marcela; Kuznetsov, Andrey V.; Michel, Lauriane; Cottet-Rousselle, Cecile; Saaremäe, Merle; Käämbre, Tuuli; Metsis, Madis; Grimm, Michael; Auffray, Charles; Saks, Valdur (2011). Mitochondria cytoskeleton interaction: Distribution of beta-tubulins in cardiomyocytes and HL-1 cells. Biochimica et Biophysica Acta (BBA) – Bioenergetics, 1807 (4), 458−469. DOI: 10.1016/j.bbabio.2011.01.010
Martma, K.; Habicht, K.-L.; Martinez Ramirez, X.; Tepp, K.; Käämbre, T.;
Volobujeva, O.; Shimmo, R. (2011). Polydopamine as an adhesive coating for open tubular capillary electrochromatography. Electrophoresis, 32 (9), 1054−1060. DOI:10.1002/elps.201000569.
Karu-Varikmaa, M.; Metsis, M.; Guzun, R.; Käämbre, T.; Grichine, A.; Saks, V.
(2011). Investigation of interactions between mitochondrial creatine kinase and ATP/ADP channel. FEBS Journal, 278, 374−375.
Tepp, K.; Shevchuk, I.; Chekulayev, V.; Timohhina, N.; Saks, V.; Käämbre, T. (2011). High efficiency of energy flux control with mitochondrial interactosome in cardiac cell. FEBS Journal, 278, 377−377.
Saks, V.; Aliev, M.; Tepp, K.; Karu-Varikmaa, M.; Chekulaev, V.; Shevchuk, I.;
Käämbre, T.; Guzun, R. (2011). Quantitative Analysis of Integrated Energy
Metabolism of Muscle Cells: Experimental and Theoretical Studies. Biophysical Journal, 100, 2a−2a.
Gonzalez-Granillo, M.A.; Karu-Varikmaa, M.; Saaremäe, M.; Michel, L.; Käämbre,
T.; Saks, V.; Guzun, R. (2011). Mitochondrial Interactosome in Energy Metabolism in Healthy and Cancer Cells. Biophysical Journal, 100, 298a−298a.
Karu-Varikmaa, M.; Saaremäe, M.; Sikk, P.; Käämbre, T.; Metsis, M.; Saks, V.
(2011). Regulation of Mitochondrial Respiration by Different Tubulin Isoforms in Vivo. Biophysical Journal, 100, 459a−459a.

Earlier

Tepp, Kersti; Timohhina, Natalya; Chekulayev, Vladimir; Shevchuk, Igor; Kaambre, Tuuli; Saks, Valdur (2010). Metabolic control analysis of integrated energy metabolism in permeabilized cardiomyocytes – experimental study. Acta Biochimica Polonica, 57 (4), 421−430.
Saks, Valdur; Guzun, Rita; Timohhina, Natalja; Tepp, Kersti; Varikmaa, Minna;
Monge, Claire; Beraud, Nathalie; Käämbre, Tuuli; Kuznetsov, Andrey; Kadaja,
Lumme; Eimre, Margus; Seppet, Enn (2010). Structure-function relationships in feedback regulation of energy fluxes in vivo in health and disease: Mitochondrial Interactosome. Biochimica et Biophysica Acta, 1797 (6-7), 678−697. DOI: 10.1016/j.bbabio.2010.01.011.
Guerrero, K.; Monge, C.; Brückner, A.; Puurand, U.; Kadaja, L.; Käämbre, T.; Seppet, E.; Saks, V. (2010). Study of possible interactions of tubulin, microtubular network, and STOP protein with mitochondria in muscle cells. Molecular and Cellular Biochemistry, 337, 239−249. DOI: 10.1007/s11010-009-0304-1
Monge, Claire; Guzun, Rita; Tepp, Kersti; Timohhina, Natalja; Varikmaa, Minna;
Sikk, Peeter; Käämbre, Tuuli; Saks, Valdur (2010). Mitochondrial Interactosome in Health and Disease: Structural and Functional Aspects of Molecular System Bioenergetics of Muscle and Neuronal Cells. In: Oliver L. Svensson (Ed.). Mitochondria: Structure, Functions and Dysfunctions. (441−470). Nova Science Publisher Inc..
Varikmaa, Minna; Metsis, Madis; Guzun, Rita; Käämbre, Tuuli; Grichine, Alexei;
Saks, Valdur (2010). Novel Method for Investigation of Interactions between Mitochondrial Creatine Kinase and Adenine Nucleotide Translocase. Biophysical Journal, 98: Biophysical Society 54th Annual Meeting, February 20-24 , San Fransisco. 2010, 735a. (3).
Timohhina, Natalja; Guzun, Rita; Tepp, Kersti; Monge, Claire; Varikmaa, Minna; Vija, Heiki; Sikk, Peeter; Käämbre, Tuuli; Sackett, Dan; Saks, Valdur (2009). Direct measurement of energy fluxes from mitochondria into cytoplasm in permeabilized cardiac cells in situ: some evidence for mitochondrial interactosome. Journal of Bioenergetics and Biomembranes, 41 (3), 259−275.
Guzun, R.; Timohhina, N.; Tepp, K.; Monge, C.; Käämbre, T.; Sikk, P.; Kuznetsov,
AV.; Pison, C.; Saks, V. (2009). Regulation of respiration controlled by mitochondrial creatine kinase in permeabilized cardiac cells in situ importance of system level properties. Biochimica et Biophysica Acta (BBA) – Bioenergetics, 1787 (9), 1089−1105. DOI: 10.1016/j.bbabio.2009.03.024.
Monge, Claire; Beraud, Nathalie; Tepp, Kersti; Pelloux, Sophie; Chahboun, Siham;
Käämbre, Tuuli; Kadaja, Lumme; Roosimaa, Mart; Piirsoo, Andres; Tourneur, Yves; Kuznetsov, Andrey V; Saks, Valdur; Seppet, Enn (2009). Comparative analysis of the bioenergetics of adult cardiomyocytes and nonbeating HL-1 cells: respiratory chain activities, glycolytic enzyme profiles, and metabolic fluxes. Canadian Journal of Physiology and Pharmacology, 87 (4), 318−326.
Sikk, Peeter; Käämbre, Tuuli; Vija, Heiki; Tepp, Kersti; Tiivel, Toomas; Nutt, Anu;
Saks, Valdur (2009). Ultra performance liquid chromatography analysis of adenine nucleotides and creatine derivatives for kinetic studies. Proceedings of the Estonian Academy of Sciences, 58 (2), 122−131.
Sepp, Mervi; Kaambre, Tuuli; Sikk, Peeter; Vendelin, Marko; Birkedal, Rikke (2009). Kinetic studies of intracellular compartmentalization in permeabilized rat cardiomyocytes. The Journal of Physiological Sciences, 59, 362.
Käämbre, Tuuli; Sikk, Peeter; Anmann, Tiia; Tiivel, Toomas; Timohhina, Natalja;
Nutt, Anu; Tepp, Kersti; Saks, Valdur (2008). Südamelihase rakkude struktuuri olulisusest rakuhingamise regulatsioonis. Eesti Arst, 1, 19−22.
Saks, V.; Kaambre, T.; Guzun, R.; Anmann, T.; Sikk, P.; Schlattner, U.; Wallimann,
T.; Aliev, M.; Vendelin, M. (2007). The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approaches. In: Salomons, G.S.; Wyss, M. (Ed.). Creatine and Creatine Kinase in Health and Disease. (27−65). Dordrecht: Springer. (Subcellular Biochemistry; 46). DOI: 10.1007/978-1-4020-6486-9_3.
Anmann, T.; Guzun, R.; Beraud, N.; Pelloux, S.; Kuznetsov, A.V.; Kogerman, L.;
Kaambre, T.; Sikk, P.; Paju, K.; Peet, N.; Seppet, E.; Ojeda, C.; Tourneur, Y.; Saks, V. (2006). Different kinetics of the regulation of respiration in permeabilized cardiomyocytes and in HL-1 cardiac cells – Importance of cell structure/organization for respiration regulation. Biochimica et Biophysica Acta (BBA) – Bioenergetics, 1757 (12), 1597−1606 . DOI: 10.1016/j.bbabio.2006.09.008
Seppet, E.K.; Eimre, M.; Anmann, T.; Seppet, E.; Piirsoo, A.; Peet, N.; Paju, K.;
Guzun, R.; Beraud, N.; Pelloux, S.; Tourneur, Y.; Kuznetsov, A.V.; Käämbre, T.; Sikk, P.; Saks, V.A. (2006). Structure-function relationships in regulation of the energy transfer between mitochondria and ATPases in cardiac cells. Experimental and Clinical Cardiology, 11 (3), 189−194.
Seppet, E.K.; Eimre, M.; Paju, K.; Orlova, E.; Piirsoo, A.; Sikk, P.; Kaambre, T.; Saks, VA. (2006). Calcium-induced contraction of sarcomeres changes the interaction between mitochondria and ATPases in permeabilized cardiac cells. Journal of Molecular and Cellular Cardiology, 40 (6), 931−931.
Eimre, M.; Seppet, E.; Paju, K.; Orlova, E.; Piirsoo, A.; Sikk, P.; Käämbre, T.; Saks,
V. (2006). Kaltsiumist põhjustatud sarkomeeride kontraktsioon muudab mitokondrite ja ATPaaside vahelist interaktsiooni permeabiliseeritud südamerakkudes. 85. , 645−646.
Anmann, T.; Eimre, M.; Kuznetsov, AV.; Andrienko, T.; Kaambre, T.; Sikk, P.;
Seppet, E.; Tiivel, T.; Vendelin, M.; Seppet, E.; Saks, VA. (2005). Calcium-induced contraction of sarcomeres changes the regulation of mitochondrial respiration in permeabilized cardiac cells. FEBS Journal, 272 (12), 3145−3161. DOI:10.1111/j.1742-4658.2005.04734.x.
Seppet, E. K.; Eimre, M.; Anmann, T.; Seppet, E.; Peet, N.; Käämbre, T.; Paju, K.;
Piirsoo, A.; Kuznetsov, A. V.; Vendelin, M.; Gellerich, F. N.; Zierz, S.; Saks, V. A.
(2005). Intracellular energetic units in healthy and diseased hearts. Experimental and Clinical Cardiology, 10 (3), 173−183.
Seppet, EK.; Eimre, M.; Kaambre, T.; Piirsoo, A. (2005). Compartmentation of energy metabolism in heart cells: Structure-function relationships. JOURNAL OF
MOLECULAR AND CELLULAR CARDIOLOGY, 38. , 1065−1066.
Seppet, EK.; Eimre, M.; Andrienko, T.; Kaambre, T.; Sikk, P.; Kuznetsov, AV.; Saks,V. (2004). Studies of mitochondrial respiration in muscle cells in situ: Use and misuse of experimental evidence in mathematical modelling. Molecular and Cellular Biochemistry, 256, 219−227.
Saks, V.; Andrienko, T.; Kuznetsov, A.; Zorov, D; Käämbre, T.; Sikk, P. (2004). Ca2+ contraction and mitochondria in heart: A mechanochemical link? 86. , 336A−337A.
Andrienko, T.; Kuznetsov, A.V.;Kaambre, T.; Usson, Y.; Orosco, A.; Appaix, F.;
Tiivel, T.; Sikk, P.; Vendelin, M.; Margreiter, R.; Saks, V.A. (2003). Metabolic
consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cells. Journal of Experimental Biology, 206 (12), 2059−2072.
Saks, Valdur; Kuznetsov, Andrey; Andrienko, Tatiana; Usson, Yves; Appaix,
Florence; Guerrero, Karen; Kaambre, Tuuli; Sikk, Peeter; Lemba, Maris; Vendelin,
Marko (2003). Heterogeneity of ADP diffusion and regulation of respiration in cardiac cells. Biophysical Journal, 84 (5), 3436−3456. DOI: 10.1016/S0006-3495(03)70065-4.
Appaix, F.; Kuznetsov, A. V.; Usson, Y.; Kay, L.; Andrienko, T.; Olivares, J.;
Kaambre, T.; Sikk, P.; Margreiter, R.; Saks, V. (2003). Possible role of cytoskeleton in intracellular arrangement and regulation of mitochondria. Experimental Physiology, 88, 175−190. DOI: 10.1113/eph8802511
Appaix, F.; Guerrero, K.; Rampal, D.; Izikki, M.; Kaambre, T.; Sikk, P.; Brdiczka, D.; Riva-Lavieille, C.; Olivares, J.; Longuet, M.; Antonsson, B.; Saks, V. (2002). Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition. Biochimica et Biophysica Acta, 1556, 156−167.
Seppet, EK.; Kadaja, L.; Braun, U.; Kisand, K.; Metskula, K.; Uibo, R.; Kaambre, T.; Valdur, A. (2002). Intracellular energetic units in cardiac cells: Targets in primary biliary cirrhosis. Journal of Molecular and Cellular Cardiology, 34 (6), A57−A57.
Seppet, EK.; Kaambre, T.; Sikk, P.; Tiivel, T.; Vija, H.; Tonkonogi, M.; Sahlin, K.;
Kay, L.; Appaix, F.; Braun, U.; Eimre, M.; Saks, VA. (2001). Functional complexes of mitochondria with Ca,MgATPases of myofibrils and sarcoplasmic reticulum in muscle cells. Biochimica et Biophysica Acta (BBA) – Bioenergetics, 1504, 379−395. DOI: 10.1016/S0005-2728(00)00269-3.
Saks, VA.; Kaambre, T.; Sikk, P.; Eimre, M.; Orlova, E.; Paju, K.; Piirsoo, A.; Appaix, F.; Kay, L.; Regitz-Zagrosek, V.; Fleck, E.; Seppet, E. (2001). Intracellular energetic units in red muscle cells. Biochemical Journal, 356, 643−657.
Saks, V.; Kay, L.; Sikk, P.; Kaambre, T.; Seppet, E.; Piirsoo, A. (2001). Intracellular energetic units in muscle cells? Biophysical Journal, 80 (1), 583A−583A.
Tiivel, T.; Kadaya, L.; Kuznetsov, A.; Kaambre, T.; Peet, N.; Sikk, P.; Braun, U.;
Ventura-Clapier, R.; Saks, V.; Seppet, EK. (2000). Developmental changes in
regulation of mitochondrial respiration by ADP and creatine in rat heart in vivo. Molecular and Cellular Biochemistry, 208, 119−128.
Saks, VA.; Tiivel, T.; Sikk, P.; Kaambre, T.; Kay, L.; Tonkonogi, M.; Seppet, E.;
Sahlin, K. (2000). Metabolic channelling in cardiac cells: Dependence of kinetics of respiration regulation on source of ADP. Biophysical Journal, 78 (1), 197A−197A.