{"id":4838,"date":"2020-07-02T10:57:46","date_gmt":"2020-07-02T07:57:46","guid":{"rendered":"http:\/\/kbfi.ee\/?page_id=4838"},"modified":"2025-07-03T14:44:37","modified_gmt":"2025-07-03T11:44:37","slug":"defended-theses","status":"publish","type":"page","link":"https:\/\/kbfi.ee\/en\/cb\/research\/defended-theses\/","title":{"rendered":"Defended Theses"},"content":{"rendered":"

Ph.D. theses<\/strong><\/h2>\n

Sten Miller,<\/a> 2025<\/strong> Energy Metabolism of Cancer: Unravelling Complexities Through Multiparameter Metabolic Analysis. Supervisors Tuuli K\u00e4\u00e4mbre and Aleksandr Klepinin, Tallinn University of Technology, Department of Chemistry and Biotechnology.<\/p>\n

Leenu Reinsalu,<\/a> 2024<\/strong> Metabolic Reprogramming Accompanying the Development of Colorectal Cancer. Supervisor Tuuli K\u00e4\u00e4mbre, Tallinn University of Technology, Department of Chemistry and Biotechnology.<\/p>\n

Jekaterina Aid,<\/a> 2024<\/strong> Influence of Intrinsic and Extrinsic Factors on Mitochondrial Energy Metabolism in the Heart.\u00a0 Supervisors Tuuli K\u00e4\u00e4mbre, Kersti Tepp and Marju Puurand, Tallinn University of Technology, Department of Chemistry and Biotechnology.<\/p>\n

Laura Truu,<\/a> 2024<\/strong> The Permeability of Mitochondrial Outer Membrane and Metabolic Plasticity in Colorectal Cancer. Supervisor Tuuli K\u00e4\u00e4mbre, Tallinn University of Technology, Department of Chemistry and Biotechnology.<\/p>\n

Egle Rebane-Klemm<\/a>, 2023<\/strong> Metabolic Alteration in Colorectal Polyps and their Role in Carcinogenesis. Supervisor Tuuli K\u00e4\u00e4mbre, Tallinn University of Technology, Department of Chemistry and Biotechnology.<\/p>\n

Ljudmila Klepinina<\/a>, 2021<\/strong>. Rearrangement of Energy Metabolism During Differentiation of Cancer Cells. Supervisor\u00a0Tuuli K\u00e4\u00e4mbre, Tallinn University of Technology, Department of Chemistry and Biotechnology.<\/p>\n

Andre Koit<\/a>, 2018<\/strong>. Malignant Transformation Causes Rearrangement of Energy Metabolism in Colorectal and Breast Cancers. Supervisors Tuuli K\u00e4\u00e4mbre ja Vahur Valvere, Tallinn University of Technology, Department of Chemistry and Biotechnology.<\/p>\n

Andrus Kaldma<\/a>, 2017.<\/strong> Metabolic Remodeling of Human Colorectal Cancer: Alterations in Energy Fluxes. Supervisors Tuuli K\u00e4\u00e4mbre ja Natalja Timohhina, Tallinn University of Technology, Department of Chemistry and Biotechnology.<\/p>\n

Minna Varikmaa<\/a>, 2013<\/strong>. \u00a0Structural and functional studies of mitochondrial respiration regulation in muscle cells. Supervisors Valdur Saks, Madis Metsis. Tallinn University of Technology, Faculty of Science, Department of Chemistry, Center for Biology of Integrated Systems.<\/p>\n

Kersti Tepp<\/a>, 2011<\/strong>. Molecular system bioenergetics of cardiac cells: Quantitative analysis of structure-function relationship. Supervisors Valdur Saks, Raivo Vilu. Tallinn University of Technology, Faculty of Science, Department of Chemistry.<\/p>\n

Natalja Timohhina<\/a>, 2011<\/strong>. Molecular system bioenergetics of the heart cells: Mitochondrial Interactosome. Supervisors Valdur Saks, Tuuli K\u00e4\u00e4mbre. Tallinn University, Institute of Mathematics and Natural Sciences.<\/p>\n

Tiia Anmann<\/a>, 2007<\/strong>. Integrated and organized cellular bioenergetic systems in heart and brain. Supervisors Valdur Saks, Raivo Vilu. Tallinn University of Technology, Faculty of Science, Department of Chemistry.<\/p>\n

Tuuli K\u00e4\u00e4mbre<\/a>, 2004<\/strong>. Intracellular energetic units: Structural and functional aspects. Supervisors Enn Seppet, Valdur Saks. Tartu University, Faculty of Medicine.<\/p>\n

Toomas Tiivel, 2002.<\/span><\/strong> The role of the mitochondrial outer membrane in in vivo regulation of respiration in normal heart and skeletal muscle cells. (\u00c9tude contr\u00f4le de la respiration mitochondrial des cellules musculaires-r\u00f4le de la membrane externe). Supervisors Valdur Saks, Andr\u00e9 Rossi, Enn Seppet. Tallinn University of Technology, Joseph Fourier University (Grenoble, France).<\/p>\n

Master’s theses<\/strong><\/h2>\n

Marie P\u00f5lluaed<\/a>, 2025<\/strong> The effects of physioxia and cell media on oxidative stress markers in neuronal and liver cancer cell lines Supervisors Rutt Taba and Anton Terasmaa.\u00a0 Tallinn University of Technology, Department of Chemistry and Biotechnology.<\/p>\n

Leenu Reinsalu, 2020<\/strong>. Metabolic Reprogramming in Colorectal Cancer and Colon Polyps. Supervisors Tuuli K\u00e4\u00e4mbre and Egle Rebane-Klemm. Tallinn University of Technology, Department of Chemistry and Biotechnology.<\/p>\n

Sten Miller, 2020<\/strong>. Optimization and application of stable isotope mass spectrometry method to study breast cancer energy metabolism. Supervisors Aleksandr Klepinin and Tuuli K\u00e4\u00e4mbre. Tallinn University of Technology, Department of Chemistry and Biotechnology.<\/p>\n

Kaisa Kuus, 2018<\/strong>. Expression of pluripotency related marker proteins in human colorectal adenocarcinoma Caco2 cells. Supervisors Martin Pook, Aleksandr Klepinin and Ljudmila Klepinina. University of Tartu, Faculty of Science and Technology, Institute of Molecular and Cell Biology.<\/p>\n

Aivar Uus<\/a>, 2016<\/strong>. Energia\u00fclekande v\u00f5rgustiku profiili arengulised ja vananemisega seotud muutused kardiom\u00fcots\u00fc\u00fctides. Supervisors Kersti Tepp and Kairi Koort. Tallinn University, School of Natural Sciences and Health.<\/p>\n

Aleksandr Klepinin<\/a>, 2014<\/strong>. Comparative analysis of mitochondrial metabolism in differentiated and undifferentiated neuroblastoma cells. Supervisors Tuuli K\u00e4\u00e4mbre, Igor Shevchuk. Tallinn University of Technology, Faculty of Science, Department of Gene Technology.<\/p>\n

Aia Simm<\/a>, 2011<\/strong>. Comparative bioenergetics of nerve cells. Supervisors Tuuli K\u00e4\u00e4mbre, Tiit Land. Tallinn University, Institute of Mathematics and Natural Sciences.
\nDiploma for the Master thesis on health research on National Science Contest for university level students.<\/p>\n

Merle Saarem\u00e4e, 2010.<\/span><\/strong> Expression and role of beta-tubulin isoforms in regulation of permeability of mitochondrial outer membrane. Supervisors Tuuli K\u00e4\u00e4mbre, Sirje R\u00fc\u00fctel Boudinot. Tallinn University of Technology, Faculty of Science, Department of Gene Technology.
\nIst prize for the Master thesis on health research on National Science Contest for university level students.<\/p>\n

Bachelor’s theses<\/h3>\n

Maari Tamm, 2013.<\/span> Determination of the bioenergetic profile in Neuro-2a cells. Supervisors Kersti Tepp, Natalja Timohhina. Tallinn University, Institute of Mathematics and Natural Sciences.<\/p>\n

Ott Kaljula, 2013.<\/span> Determination of metabolic parameters of colorectal cancer in clinical samples. Supervisors Kersti Tepp, Natalja Timohhina. Tallinn University, Institute of Mathematics and Natural Sciences.<\/p>\n

Tuuli Tamm, 2009.<\/span> Regulation of mitochondrial respiration in cardiac cells in vivo. Supervisor Tuuli K\u00e4\u00e4mbre. Tallinn University, Institute of Mathematics and Natural Sciences.<\/p>\n

Aia Simm, 2008.<\/span> The new procedure of preparation of cardiac myocytes. Supervisor Tuuli K\u00e4\u00e4mbre. Tallinn University, Institute of Mathematics and Natural Sciences.<\/p>\n

Priit Hani, 2007.<\/span> Function of creatine kinase in heart muscle cells in intracellular energetic unit. Supervisor Tuuli K\u00e4\u00e4mbre. Tallinn University, Institute of Mathematics and Natural Sciences.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ph.D. theses Sten Miller, 2025 Energy Metabolism of Cancer: Unravelling Complexities Through Multiparameter Metabolic Analysis. Supervisors Tuuli K\u00e4\u00e4mbre and Aleksandr Klepinin, Tallinn University of Technology, Department of <\/a><\/p>\n","protected":false},"author":33,"featured_media":0,"parent":1382,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-4838","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/pages\/4838"}],"collection":[{"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/users\/33"}],"replies":[{"embeddable":true,"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/comments?post=4838"}],"version-history":[{"count":0,"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/pages\/4838\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/pages\/1382"}],"wp:attachment":[{"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/media?parent=4838"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}