{"id":3078,"date":"2018-11-27T11:30:57","date_gmt":"2018-11-27T09:30:57","guid":{"rendered":"http:\/\/kbfi.ee\/?page_id=3078"},"modified":"2026-02-25T17:52:26","modified_gmt":"2026-02-25T15:52:26","slug":"publications","status":"publish","type":"page","link":"https:\/\/kbfi.ee\/en\/cb\/research\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<style>\n* {box-sizing: border-box;}<br \/>.timeline {<br \/>position: relative;<br \/>display: block;<br \/>margin: 0 auto;<br \/>height: 5px;<br \/>background-color: #428bca;<br \/>}<br \/>.timeline_content{<br \/>display:inline-block;<br \/>color:black;<br \/>padding:10px;<br \/>position: relative;<br \/>width: 8%;<br \/>float: right;<br \/>}<br \/>.timeline_content::after {<br \/>content: \"\";<br \/>display: block;<br \/>background:white;<br \/>width: 10px;<br \/>height: 10px;<br \/>border-radius: 7px;<br \/>border:3px solid #428bca;<br \/>position:absolute;<br \/>top: -3%;<br \/>margin-left: 0;<br \/>}<br \/>.timeline_content:hover::after{<br \/>width:20px;<br \/>height:20px;<br \/>border-radius:12px;<br \/>cursor: pointer;<br \/>background-color:#428bca;<br \/>top: -11%;<br \/>margin-left: -6px;<br \/>}<br \/>.timeline_content h2{<br \/>font-size: 1.5vw;<br \/>margin-left: -18px;<br \/>color: #444444;<br \/>}<br \/>.publications_load{<br \/>margin-top:10%;<br \/>}<br \/>.prev, .next{<br \/>  background-color: #428bca;<br \/>  border: none;<br \/>    color: white;<br \/>    padding: 5px 10px;<br \/>    text-align: center;<br \/>    display: inline-block;<br \/>    font-size: 32px;<br \/>    cursor: pointer;<br \/>    border-radius: 20px;<br \/>}<br \/>.publicationYear p{<br \/>font-size: 1.1em;<br \/>color: #444444;<br \/>}<br \/>.publicationYear h4{<br \/>font-size: 1.25em;<br \/>}<br \/>li:hover {<br \/>  background: #458ece40;<br \/>}<br \/><\/style>\n<section class=\"timeline\">\n<div id=\"Vanemad\" class=\"timeline_content\">\n<section class=\"timeline\">\n<div id=\"Vanemad\" class=\"timeline_content\">\n<h3>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0<a href=\"https:\/\/kbfi.ee\/kb\/teadustoo\/2021-2\/\">2021<\/a> &#8211; <a href=\"https:\/\/kbfi.ee\/kb\/teadustoo\/2020-2\/\">2020<\/a> &#8211; <a href=\"https:\/\/kbfi.ee\/kb\/teadustoo\/2019-2\/\">2019<\/a> &#8211; <a href=\"https:\/\/kbfi.ee\/kb\/teadustoo\/2018-2\/\">2018<\/a> &#8211;\u00a0<a href=\"https:\/\/kbfi.ee\/en\/cb\/research\/2017-2\/\">2017<\/a> &#8211;\u00a0<a href=\"https:\/\/kbfi.ee\/en\/cb\/research\/2016-2\/\">2016<\/a> &#8211;\u00a0<a href=\"https:\/\/kbfi.ee\/kb\/teadustoo\/2015-2\/\">2015<\/a> &#8211;\u00a0<a href=\"https:\/\/kbfi.ee\/en\/cb\/research\/2014-2\/\">2014<\/a> &#8211;\u00a0<a href=\"https:\/\/kbfi.ee\/en\/cb\/research\/2013-2\/\">2013<\/a> &#8211;\u00a0<a href=\"https:\/\/kbfi.ee\/en\/cb\/research\/2012-2\/\">2012<\/a> &#8211;\u00a0<a href=\"https:\/\/kbfi.ee\/en\/cb\/research\/2011-2\/\">2011<\/a> &#8211; <a href=\"https:\/\/kbfi.ee\/en\/cb\/research\/2010-2\/\">2010<\/a> &#8211; <a href=\"https:\/\/kbfi.ee\/en\/cb\/research\/2009-2\/\">2009<\/a> Earlie<\/h3>\n<h3>\u00a02025<\/h3>\n<p>Marju Puurand, Rutt Taba, Kersti Tepp, Anton Terasmaa, Tuuli K\u00e4\u00e4mbre <strong>V\u00e4hkkasvajate paindlikust ainevahetusest v\u00f5ib saada nende Achilleuse kand. <\/strong>ERR <a href=\"https:\/\/novaator.err.ee\/1609730853\/vahkkasvajate-paindlikust-ainevahetusest-voib-saada-nende-achilleuse-kand\">Novaator, 26.06.2025<\/a><\/p>\n<p>Moreno-Sanchez, Rafael; Vargas-Navarro, Jorge Luis; Padilla-Flores, Joaqu\u00edn Alberto; Robledo-Cadena, Diana Xochiquetzal; Granados-Rivas, Juan Carlos; Taba, Rutt; Terasmaa, Anton; Auditano, Giuseppe Leonardo; Kaambre, Tuuli; Rodr\u00edguez Enr\u00edquez, Sara (2025). <strong>Energy Metabolism Behavior and Response to <\/strong><strong>Microenvironmental Factors of the Experimental Cancer Cell Models Differ From That of Actual Human Tumors.<\/strong> Mini-Reviews in Medicinal Chemistry, 25 (4), 319\u2212339. DOI: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39411957\/\">10.2174\/0113895575322436240924101642.<\/a><\/p>\n<p>Taba, Rutt; P\u00f5lluaed, Marie; Tein, Karin; Puurand, Marju; K\u00e4\u00e4mbre, Tuuli; Terasmaa, Anton (2025). <strong>Effect of Media Composition and Oxygen Tension on Cellular Stress Response and Nrf2 Activation in HepG2ARE Cells.<\/strong> Antioxidants, 14 (2), 137. <a href=\"https:\/\/www.mdpi.com\/2076-3921\/14\/2\/137\">DOI: 10.3390\/antiox14020137.<\/a><\/p>\n<p>Reinsalu, Leenu; Miller, Sten; Auditano, Giuseppe Leonardo; Puurand, Marju; Moreno-Sanchez, Rafael; Saavedra, Emma; Valvere, Vahur; K\u00e4\u00e4mbre, Tuuli (2025). <strong>Energy Metabolism Profiling of Human Colorectal Tumours.<\/strong> Journal of Cellular and Molecular Medicine, 29 (5), e70462. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.70462\">DOI: 10.1111\/jcmm.70462.<\/a><\/p>\n<p>Puurand, Marju; Llorente, Alicia; Line, Aija; Kaambre, Tuuli (2025). <strong>Exercise-induced extracellular vesicles in reprogramming energy metabolism in cancer.<\/strong> Frontiers in Oncology, 14, ARTN 1480074. <a href=\"https:\/\/www.frontiersin.org\/journals\/oncology\/articles\/10.3389\/fonc.2024.1480074\/full\">DOI: 10.3389\/fonc.2024.1480074.<\/a><\/p>\n<p>Tepp, Kersti; Auditano, Giuseppe Leonardo; Puurand, Marju; Kaambre, Tuuli (2025). <strong>Reliability of Pesticide Toxicity Evaluation: Effects of Pesticides on Cellular <\/strong><strong>Respiration under Conventional Versus Physiological Growth Conditions. <\/strong>Environmental Toxicology and Pharmacology,\u00a0 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S138266892500050X?via%3Dihub\">DOI: 10.1016\/j.etap.2025.104675. 104675.<\/a><\/p>\n<h3>2024<\/h3>\n<p>Sarsenova, Meruert; Lawarde, Ankita; Pathare, Amruta D. S.; Saare, Merli; Modhukur, Vijayachitra; Soplepmann, Pille; Terasmaa, Anton; K\u00e4\u00e4mbre, Tuuli; Gemzell Danielsson, Kristina; Lalitkumar, Parameswaran Grace Luther; Salumets, Andres; Peters, Maire (2024). <strong>Endometriotic lesions exhibit distinct metabolic signature compared to paired eutopic endometrium at the single-cell level.<\/strong> In: Endometriotic lesions exhibit distinct metabolic signature compared to paired eutopic endometrium at the single-cell level<br \/>\nBioRxiv: Cold Spring Harbor Laboratory. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.02.27.580606v1\">DOI: 10.1101\/2024.02.27.580606.<\/a><\/p>\n<p>Aid, Jekaterina; Tanjeko, Ajime Tom; Serre, Jef; Eggelbusch, Moritz; Noort, Wendy; de Wit, Gerard M. J.; van Weeghel, Michel; Puurand, Marju; Tepp, Kersti; Gayan Ramirez, Ghislaine; Degens, Hans; Kaambre, Tuuli; Wust, Rob C. I. (2024). <strong>Smoking cessation only partially reverses cardiac metabolic and structural remodeling in mice.<\/strong> Acta Physiologica. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.14145\">DOI: 10.1111\/apha.14145.<\/a><\/p>\n<p>Llorente, Alicia; Brok\u0101ne, Agnese; Mlynska, Agata; Puurand, Marju; Sagini, Krizia; Folkmane, Signe; Hjorth, Marit; Martin\u2010Gracia, Beatriz; Romero, Silvana; Skorinkina, Diana; \u010campa, M\u0101rti\u0146\u0161; Ce\u0161eiko, R\u016bdolfs; Romanchikova, Nadezhda; K\u013cavi\u0146a, Aija; K\u00e4\u00e4mbre, Tuuli; Lin\u0113, Aija (2024). <strong>From sweat to hope: The role of exercise\u2010induced extracellular vesicles in cancer prevention and treatment.<\/strong> Journal of Extracellular Vesicles, 13 (8), e12500. <a href=\"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jev2.12500\">DOI: 10.1002\/jev2.12500.<\/a><\/p>\n<p>Sarsenova, Meruert; Lawarde, Ankita; Pathare, Amruta D S; Saare, Merli; Modhukur, Vijayachitra; Soplepmann, Pille; Terasmaa, Anton; K\u00e4\u00e4mbre, Tuuli; Gemzell Danielsson, Kristina; Lalitkumar, Parameswaran Grace Luther; Salumets, Andres; Peters, Maire (2024). <strong>Endometriotic lesions exhibit distinct metabolic signature compared to paired eutopic endometrium at the single-cell level.<\/strong> Communications Biology, 7 (1), 1026. <a href=\"https:\/\/www.nature.com\/articles\/s42003-024-06713-5\">DOI: 10.1038\/s42003-024-06713-5.<\/a><\/p>\n<p>Rodr\u00edguez-Enr\u00edquez, S.; Robledo-Cadena, D.X.; Pacheco-Vel\u00e1zquez, S.C.; Vargas Navarro, J.L.; Padilla-Flores, J.A.; Kaambre, T.; Moreno-S\u00e1nchez, R. (2024). <strong>Repurposing auranofin and meclofenamic acid as energy-metabolism inhibitors and anti-cancer drugs.<\/strong> PLoS ONE, 19 (9), 1\u221222. <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0309331\">DOI: 10.1371\/journal.pone.0309331.<\/a><\/p>\n<p>Robledo-Cadena, Diana Xochiquetzal; Pacheco-Vel\u00e1zquez, Silvia Cecilia; Vargas Navarro, Jorge Luis; Padilla-Flores, Joaqu\u00edn Alberto; L\u00f3pez-Marure, Rebeca; P\u00e9rez Torres, Israel; Kaambre, Tuuli; Moreno-S\u00e1nchez, Rafael; Rodr\u00edguez-Enr\u00edquez, Sara (2024). <strong>Synergistic celecoxib and dimethyl-celecoxib combinations block cervix <\/strong><strong>cancer growth through multiple mechanisms.<\/strong> PLoS ONE, 19 (9), e0308233. <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0308233\">DOI:10.1371\/journal.pone.0308233.<\/a><\/p>\n<h3>2023<\/h3>\n<p>Rebane-Klemm, Egle; Reinsalu, Leenu; Puurand, Marju; Shevchuk, Igor; Bogovskaja, Jelena; Suurmaa, Kulliki; Valvere, Vahur; Moreno-Sanchez, Rafael; Kaambre, Tuuli(2023). <strong>Colorectal polyps increase the glycolytic activity.<\/strong> Frontiers in Oncology, 13, 1171887. <a href=\"https:\/\/www.frontiersin.org\/journals\/oncology\/articles\/10.3389\/fonc.2023.1171887\/full\">DOI: 10.3389\/fonc.2023.1171887.<\/a><\/p>\n<p>Puurand, Marju; Tepp, Kersti; K\u00e4\u00e4mbre, Tuuli (2023). <strong>Diving into cancer OXPHOS The application of metabolic control analysis to cell and tissue research.<\/strong> Biosystems, 105032. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0303264723002071\">DOI: 10.1016\/j.biosystems.2023.105032.<\/a><\/p>\n<p>Auditano, Giuseppe Leonardo; Kullison, Karolin; Kaambre, Tuuli; Tepp, Kersti (2023). <strong>The Effects of Pesticides on the Bioenergetics of Intestinal Cells.<\/strong> International Conference EcoBalt 2023 &#8220;Chemicals &amp;amp; Environment&#8221;, 92. MDPI, 66. (1). <a href=\"https:\/\/www.mdpi.com\/2504-3900\/92\/1\/66\">DOI: 10.3390\/proceedings2023092066.<\/a><\/p>\n<h3>2022<\/h3>\n<p>Tepp, Kersti; Aid-Vanakova, Jekaterina; Puurand, Marju; Timohhina, Natalja; Reinsalu, Leenu; Tein, Karin; Plaas, Mario; Shevchuk, Igor; Terasmaa, Anton; Kaambre, Tuuli; (2022). <strong>Wolframin deficiency is accompanied with metabolic <\/strong><strong>inflexibility in rat striated muscles.<\/strong> Biochemistry and Biophysics Reports, 30, 101250. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405580822000504\">DOI: 10.1016\/j.bbrep.2022.101250.<\/a><\/p>\n<p>Klepinin, Aleksandr; Miller, Sten; Reile, Indrek; Puurand, Marju; Rebane-Klemm, Egle; Klepinina, Ljudmila; Vija, Heiki; Zhang, Song; Terzic, Andre; Dzeja, Petras; and K\u00e4\u00e4mbre, Tuuli (2022). <strong>Stable isotope tracing uncovers reduced \u03b3\/\u03b2-ATP turnover and metabolic flux through mitochondrial-linked phosphotransfer circuits in aggressive breast cancer cells.<\/strong> Frontiers in Oncology, 12 (Cancer Metabolism), <a href=\"https:\/\/www.frontiersin.org\/journals\/oncology\/articles\/10.3389\/fonc.2022.892195\/full\">892195. DOI: 10.3389\/fonc.2022.892195.<\/a><\/p>\n<p>Kaambre, Tuuli (2022). <strong>Editorial: Women in cancer metabolism<\/strong> 2021\/2022. Frontiers in Oncology, 12, ARTN 1042349. <a href=\"https:\/\/www.frontiersin.org\/journals\/oncology\/articles\/10.3389\/fonc.2022.1042349\/full\">DOI: 10.3389\/fonc.2022.1042349.<\/a><\/p>\n<h3>2021<\/h3>\n<p>Zhang, Song; Yamada, Satsuki; Park, Sungjo; Klepinin, Aleksandr; Kaambre, Tuuli; Terzic, Andre; Dzeja, Petras (2021). <strong>Adenylate kinase AK2 isoform integral in embryo and adult heart homeostasis.<\/strong> Biochemical and Biophysical Research Communications, 546, 59\u221264. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33571905\/\">DOI:10.1016\/j.bbrc.2021.01.097<\/a><\/p>\n<p>Kaup, Karl Kristjan; Toom, Lauri; Truu, Laura; Miller,Sten; Puurand, Marju; Tepp, Kersti; K\u00e4\u00e4mbre Tuuli; Reile, Indrek (2021). <strong>A line-broadening free real-time 31P Pure Shift NMR method for phosphometabolomic analysis.<\/strong> The Analyst, 146 (18), 5502\u22125507. <a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2021\/an\/d1an01198g\">DOI: 10.1039\/d1an01198g.<\/a><\/p>\n<p>Reinsalu, Leenu; Puurand, Marju; Chekulayev, Vladimir; Miller, Sten; Shevchuk, Igor; Tepp, Kersti; Rebane-Klemm, Egle; Timohhina, Natalja; Terasmaa, Anton; Kaambre, Tuuli (2021). <strong>Energy Metabolic Plasticity of Colorectal Cancer Cells as a Determinant of Tumor Growth and Metastasis.<\/strong> Frontiers in Oncology, 11, ARTN 698951. <a href=\"https:\/\/www.frontiersin.org\/journals\/oncology\/articles\/10.3389\/fonc.2021.698951\/full\">DOI: 10.3389\/fonc.2021.698951.<\/a><\/p>\n<p>Klepinina, Ljudmila; Klepinin, Aleksandr; Truu, Laura; Chekulayev, Vladimir; Vija, Heiki; Kuus, Kaisa; Teino, Indrek; Pook, Martin; Maimets, Toivo; Kaambre, Tuuli (2021). <strong>Colon cancer cell differentiation by sodium butyrate modulates metabolic <\/strong><strong>plasticity of Caco-2 cells via alteration of phosphotransfer network.<\/strong> PLoS ONE, 16 (1), ARTN e0245348. <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0245348\">DOI:10.1371\/journal.pone.0245348.<\/a><\/p>\n<h3>2020<\/h3>\n<p>Tepp, Kersti; Puurand, Marju; Timohhina, Natalja; Aid-Vanakova, Jekaterina; Reile, Indrek; Shevchuk, Igor; Chekulayev, Vladimir; Eimre, Margus; Peet, Nade\u017eda; Kadaja, Lumme; Paju, Kalju; Kaambre, Tuuli (2020). <strong>Adaptation of mice striated muscles to wolframin deficiency: alterations in cellular bioenergetics.<\/strong> Biochemica et Biophysica Acta. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0304416520300131?via%3Dihub\">DOI:10.1016\/j.bbagen.2020.129523.<\/a><\/p>\n<p>Ruiz\u2010Meana, Marisol; Boengler, Kerstin; Garcia\u2010Dorado, David; Hausenloy, Derek J.; K\u00e4\u00e4mbre, Tuuli; Kararigas, Georgios; Perrino, Cinzia; Schulz, Rainer; Ytrehus, Kirsti (2020). <strong>Ageing, sex and cardioprotection<\/strong>. British Journal of Pharmacology. <a href=\"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.14951\">DOI: 10.1111\/bph.14951<\/a><\/p>\n<p>Zuurbier, Coert J; Bertrand, Luc; Beauloye, Christoph R; Andreadou, Ioanna; Ruiz Meana, Marisol; Jespersen, Nichlas R; Kula-Alwar, Duvaraka; Prag, Hiran A; Eric Botker, Hans; Dambrova, Maija; Montessuit, Christophe; Kaambre, Tuuli; Liepinsh, Edgars; Brookes, Paul S; Krieg, Thomas (2020). <strong>Cardiac metabolism as a driver and therapeutic target of myocardial infarction<\/strong>. Journal of Cellular and Molecular Medicine. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.15180\">DOI: 10.1111\/jcmm.15180<\/a><\/p>\n<p>Aleksandr Klepinin, Song Zhang, Ljudmila Klepinina, Egle Rebane-Klemm, Andre Terzic, Tuuli Kaambre, Petras Dzeja (2020). <strong>Adenylate kinase and metabolic signaling in cancer cells.<\/strong> Frontiers in Oncology, 10, 660. <a href=\"https:\/\/www.frontiersin.org\/journals\/oncology\/articles\/10.3389\/fonc.2020.00660\/full\">DOI:10.3389\/fonc.2020.00660<\/a><\/p>\n<p>Koit, Andre; Timohhina, Natalja; Truu, Laura; Chekulayev, Vladimir; Gudlawar, Shivakumar; Shevchuk, Igor; Lepik, Katrin; Mallo, Lea; Kutner, Riina; Valvere, Vahur; Kaambre, Tuuli (2020). <strong>Metabolic and OXPHOS Activities Quantified by Temporalex vivoAnalysis Display Patient-Specific Metabolic Vulnerabilities in Human Breast Cancers.<\/strong> Frontiers in Oncology, <a href=\"https:\/\/www.frontiersin.org\/journals\/oncology\/articles\/10.3389\/fonc.2020.01053\/full\">DOI:10.3389\/fonc.2020.01053.<\/a><\/p>\n<p>Timohhina, Natalja; Cerrato, Carmine Pasquale; Kurrikoff, Kaido; Chekulayev, Vladimir; Aid-Vanakova, Jekaterina; Puurand, Marju; Tepp, Kersti; Shevchuk, Igor; Langel, Ulo; Kaambre, Tuuli (2020). <strong>Viability and mitochondrial bioenergetic <\/strong><strong>functions in human colon cancer cells are not affected by treatment with peptides <\/strong><strong>mtCPP1, UPF25, mtgCPP, and mtCPP1gHO<\/strong>. bioRxiv, 1\u221220. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.07.03.185967v1\">DOI:10.1101\/2020.07.03.185967<\/a><br \/>\n.<br \/>\nRebane-Klemm, Egle; Truu, Laura; Reinsalu, Leenu; Puurand, Marju; Shevchuk, Igor; Chekulayev, Vladimir; Timohhina, Natalja; Tepp, Kersti; Bogovskaja, Jelena; Afanasjev, Vladimir; Suurmaa, K\u00fclliki; Valvere, Vahur; K\u00e4\u00e4mbre, Tuuli (2020). <strong>Mitochondrial Respiration in KRAS and BRAF Mutated Colorectal Tumors and <\/strong><strong>Polyps. Cancers<\/strong>, 12 (4), ARTN 815. <a href=\"https:\/\/www.mdpi.com\/2072-6694\/12\/4\/815\">DOI:10.3390\/cancers12040815.<\/a><\/p>\n<h3>2019<\/h3>\n<p>Mado, Kati; Chekulayev, Vladimir; Shevchuk, Igor; Puurand, Marju; Tepp, Kersti; Kaambre, Tuuli (2019). <strong>On the role of tubulin, plectin, desmin and vimentin in the <\/strong><strong>regulation of mitochondrial energy fluxes in muscle cells<\/strong>. American Journal of Physiology &#8211; Cell Physiology, 316 (5), C657\u2212C667. DOI: 10.1152\/ajpcell.00303.2018.<\/p>\n<p>Puurand, Marju; Tepp, Kersti; Timohhina, Natalja; Aid, Jekaterina; Shevchuk, Igor; Chekulayev, Vladimir; Kaambre, Tuuli. (2019). Tubulin \u03b2II and \u03b2III Isoforms as the Regulators of VDAC Channel Permeability in Health and Disease. Cells. DOI:10.3390\/cells8030239.<\/p>\n<p>Makrecka\u2010Kuka, Marina; Liepinsh, Edgars; Murray, Andrew J.; Lemieux, H\u00e9l\u00e8ne;<br \/>\nDambrova, Maija; Tepp, Kersti; Puurand, Marju; K\u00e4\u00e4mbre, Tuuli; Han, Woo Hyun; de Goede, Paul; O\u2019Brien, Katie A.; Turan, Belma; Tuncay, Erkan; Olgar, Yusuf; Rolo, Anabela P.; Palmeira, Carlos M.; Boardman, Neoma T; W\u00fcst, Rob CI; Larsen, Terje S (2019). Altered mitochondrial metabolism in the insulin resistant heart. Acta Physiologica. DOI: 10.1111\/apha.13430.<\/p>\n<p>Gnaiger, E; Aasander, Frostner, E; Abumrad, NA; Acuna-Castroviejo, D; Adams, SH; Ahn, B; Ali, SS; Alves, MG; Amati, F; Amoedo, ND; Andreadou, I; Arago, Belenguer, M; Aral, C; Arandarcikaite, O; Armand, AS; Arnould, T; Avram, VF; Bailey, DM; Bajpeyi, S; Bajzikova, M &#8230; Zvejniece, L (2019). <strong>Mitochondrial respiratory states and rates: Building blocks of mitochondrial physiology<\/strong>. 1\u221240. DOI:10.26124\/mitofit:190001.v6.<\/p>\n<h3>2018<\/h3>\n<p>Puurand, Marju; Tepp, Kersti; Klepinin, Aleksandr; Klepinina, Lyudmila; Shevchuk, Igor; Kaambre, Tuuli (2018). <strong>Intracellular Energy-Transfer Networks and High Resolution Respirometry: A Convenient Approach for Studying Their Function. International Journal of Molecular Sciences,<\/strong> 19 (10). DOI: 10.3390\/ijms19102933<br \/>\n.<br \/>\nOunpuu, Lyudmila; Truu, Laura; Shevchuk, Igor; Chekulayev, Vladimir; Klepinin,<br \/>\nAleksandr; Koit, Andre; Tepp, Kersti; Puurand, Marju; Rebane-Klemm, Egle;<br \/>\nK\u00e4\u00e4mbre, Tuuli (2018). <strong>Comparative analysis of the bioenergetics of human <\/strong><strong>adenocarcinoma Caco-2 cell line and postoperative tissue samples from colorectal <\/strong><strong>cancer patients.<\/strong> Biochemistry and Cell Biology. DOI: 10.1139\/bcb-2018-0076.<\/p>\n<p>Klepinin, Aleksandr; Ounpuu, Lyudmila; Mado, Kati; Truu, Laura; Chekulayev,<br \/>\nVladimir; Puurand, Marju; Shevchuk, Igor; Tepp, Kersti; Planken, Anu; Kaambre,<br \/>\nTuuli (2018). <strong>The complexity of mitochondrial outer membrane permeability and <\/strong><strong>VDAC regulation by associated proteins.<\/strong> Journal of Bioenergetics and Biomembranes. DOI: 10.1007\/s10863-018-9765-9.<\/p>\n<p>Ounpuu, Ljudmila; Klepinin, Aleksandr; Niemeister, Elen; Vija, Heiki; Kaambre,<br \/>\nTuuli; (2018). The phosphotransfer network and metabolic plasticity of colon cancer cells. P7 b\/12\u2212P7 b\/12.<\/p>\n<p>Tepp, Kersti; Puurand, Marju; Klepinin, Aleksandr; Reile, Indrek; Kaambre, Tuuli;<br \/>\n(2018). Alterations in energy transfer pathways in Wfs1 deficient mice. Biochimica et Biophysica Acta (BBA) &#8211; Bioenergetics, Volume 1859, Supplement, September 2018, 1859: 20th European Bioenergetics Conference, August 25-30, 2018. Budapest, Hungary: European Bioenergetics Conference, e92.<\/p>\n<p>Truu, Laura; Rebane-Klemm, E.; Shevchuk, I.; Ounpuu, L.; Koit, A.; Chekulayev, V.; Kaambre, T.; (2018). Different regulation of mitochondrial respiration in human colorectal and breast cancer clinical samples. 20th European Bioenergetics<br \/>\nConference: European Bioenergetics Conference, August 25-30, 2018. Budapest,<br \/>\nHungary: European Bioenergetics Conference, P7 b\/15\u2212P7 b\/15.<\/p>\n<h3>2017<\/h3>\n<p>Ounpuu, Lyudmila; Klepinin, Aleksandr; Pook, Martin; Teino, Indrek; Peet, Nadezda; Paju, Kalju; Tepp, Kersti; Chekulayev, Vladimir; Shevchuk, Igor; Koks, Sulev; Maimets, Toivo; Kaambre, Tuuli (2017). <strong>2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells.<\/strong> Biochimica et Biophysica Acta (BBA) &#8211; General Subjects, 1861, 2146\u22122154. DOI: 10.1016\/j.bbagen.2017.05.020.<\/p>\n<p>Koit, Andre; Timohhina, Natalja; Chekulayev, Vladimir; Valvere, Vahur; Kaambre,<br \/>\nTuuli (2017). Abstract LB-268: <strong>Rate of temporal citrate efflux from malignant <\/strong><strong>mitochondria predicts clinical aggressiveness in breast tumors.<\/strong> Cancer Research, 77: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, LB-268\u2212LB-268. (13 Supplement). DOI: 10.1158\/1538 7445.am2017-lb-268<\/p>\n<p>Truu, L.; Koit, A.; Shevchuk, I.; Ounpuu, L.; Klepinin, A.; Chekulayev, V.;<br \/>\nTimohhina, N.; Tepp, K.; Puurand, M.; Heck, K.; Valvere, V.; Guzun, R.; Kaambre, T. (2017). Bioenergetic comparison of human colorectal and breast cancer clinical<br \/>\npatients. FEBS Journal, 284: 42nd FEBS Congress; Jerusalem, Israel; September 10 14, 2017. Wiley, 282\u2212282. (Suppl. 1).<\/p>\n<p>Ounpuu, L.; Klepinin, A.; Pook, M.; Teino, I.; Peet, N.; Paju, K.; Tepp, K.; Timohhina, N.; Chekulayev, V; Shevchuk, I.; Maimets, T.; Kaambre, T. (2017). Human embryonal carcinoma stem cells display distinct bioenergetic profile compared to normal embryonic stem cells. FEBS Journal, 284: 42nd FEBS Congress; Jerusalem, Israel; September 10\u201314, 2017. Wiley, 254\u2212255. (Suppl. 1).<\/p>\n<p>Kaambre, T.; Chekulayev, V.; Shevchuk, I.; Heck, K.; Truu, L.; Planken, A. (2017).<br \/>\nAlterations in Regulation of Mitochondrial Respiration and Metabolic Fluxes in<br \/>\nHuman Colorectal Cancer and Surrounding Tissues. BIT\u2019s 10th Annual World Cancer Congress -2017 (WCC-2017): Barcelona, Spain; 19-21, May 2017. Barcelona, Spain: 10th Annual World Cancer Congress, 100\u2212100.<\/p>\n<p>Koit, Andre; Shevchuk, Igor; Ounpuu, Lyudmila; Klepinin, Aleksandr; Chekulayev,<br \/>\nVladimir; Timohhina, Natalja; Tepp, Kersti; Puurand, Marju; Truu, Laura; Heck,<br \/>\nKaroliina; Valvere, Vahur; Guzun, Rita; Kaambre, Tuuli (2017). <strong>Mitochondrial<\/strong><br \/>\n<strong>Respiration in Human Colorectal and Breast Cancer Clinical Material Is Regulated <\/strong><strong>Differently.<\/strong> Oxidative Medicine and Cellular Longevity, 2017 (1372640), 1\u221216. DOI: 10.1155\/2017\/1372640.<\/p>\n<p>Tepp, K.; Puurand, M.; Timohhina, N.; Adamson, J.; Klepinin, A.; Truu, L.; Shevchuk, I.; Chekulayev, V.; Kaambre, T. (2017). Changes in the mitochondrial function and in the efficiency of energy transfer pathways during cardiomyocyte aging. Molecular and Cellular Biochemistry, 432 (1-2), 141\u2212158. DOI: 10.1007\/s11010-017-3005-1.<\/p>\n<p>Bagur, Rafaela; Tanguy, St\u00e9phane; Foriel, Sarah; Grichine, Alexei; Sanchez, Caroline; Pernet-Gallay, Karin; Kaambre, Tuuli; Kuznetsov, Andrey V; Usson, Yves; Boucher, Fran\u00e7ois; Guzun, Rita (2016). <strong>The impact of cardiac ischemia \/reperfusion on the mitochondria-cytoskeleton interactions.<\/strong> Biochimica et Biophysica Acta, 1862 (6), x1159\u22121171. DOI: 10.1016\/j.bbadis.2016.03.009<br \/>\n.<br \/>\nTepp, K.; Timohhina, N.; Puurand, M.; Klepinin,A.; Chekulayev, V.; Shevchuk,I.;<br \/>\nKaambre, T. (2016). <strong>Bioenergetics of the aging heart and skeletal muscles: Modern <\/strong><strong>concepts and controversies.<\/strong> Ageing Research Reviews, 28, 1\u221214. DOI: 10.1016\/j.arr.2016.04.001<\/p>\n<p>Ounpuu, Lyudmila; Klepinin, Aleksandr; Chekulayev, Vladimir; Shevchuk, Igor;<br \/>\nTimohhina, Natalja; Tepp, Kersti; Kaambre, Tuuli; (2016). On the influence of<br \/>\nmicroenvironment on bioenergetics of bowel cancer. Biochimica et Biophysica Acta<br \/>\n(BBA) &#8211; Bioenergetics, 1857, Supplement: EBEC 2016: 19th European Bioenergetics Conference, 02-07 July 2016 Riva del Garda, Italy. Elsevier, e112\u2212e113. DOI: 10.1016\/j.bbabio.2016.04.242<br \/>\n.<br \/>\nKlepinin, Aleksandr; Ounpuu, Lyudmila; Guzun, Rita; Chekulayev, Vladimir;<br \/>\nTimohhina, Natalja; Tepp, Kersti; Shevchuk, Igor; Schlattner, Uwe; Kaambre, Tuuli (2016). <strong>Simple oxygraphic analysis for the presence of adenylate kinase 1 and 2 in normal and tumor cells.<\/strong> Journal of Bioenergetics and Biomembranes, 48 (5), 531\u2212548.<\/p>\n<p>Kersti Tepp; Marju Puurand; Natalja Timohhina; Jasper Adamson; Aleksandr<br \/>\nKlepinin; Igor Shevchuk; Vladimir Chekulayev; Tuuli K\u00e4\u00e4mbre (2016). New aspects of the bioenergetics of the aging heart \u2014 Changes in Intracellular Energetic Unit. In: Paolo Bernardi (Ed.). Biochimica et Biophysica Acta (BBA) &#8211; Bioenergetics. (e100). EBEC 2016: 19th European Bioenergetics Conference, 02-07 July 2016 Riva del Garda, Italy. Elsevier. (Supplement). DOI: 10.1016\/j.bbabio.2016.04.338.<\/p>\n<h3>2015<\/h3>\n<p>Chekulayev, Vladimir; Mado, Kati; Shevchuk, Igor; Koit, Andre; Kaldma, Andrus;<br \/>\nKlepinin, Aleksandr; Timohhina, Natalja; Tepp, Kersti; Kandashvili, Manana; Ounpuu, Lyudmila; Heck, Karoliina; Truu, Laura; Planken, Anu; Valvere, Vahur; Kaambre, Tuuli (2015). Metabolic remodeling in human colorectal cancer and surrounding tissues: alterations in regulation of mitochondrial respiration and metabolic fluxes. Biochemistry and Biophysics Reports, 4, 111\u2212125.<\/p>\n<p>Guzun, Rita; Kaambre, Tuuli; Bagur, Rafaela; Grichine, Alexei; Usson, Yves;<br \/>\nVarikmaa, Minna; Anmann, Tiia; Tepp, Kersti; Timohhina, Natalja; Shevchuk, Igor; Chekulayev, Vladimir; Boucher, Francois; Dos Santos, Pierre; Schlattner, Uwe; Wallimann, Theo; Kuznetsov, Andrey; Dzeja, Petras; Aliev, Mayis; Saks, Valdur (2015). Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation. Acta Physiologica, 213 (1), 84\u2212106. DOI: 10.1111\/apha.12287<\/p>\n<h3>2014<\/h3>\n<p>Tepp, K.; Mado, K.; Varikmaa, M.; Klepinin, A.; Timohhina, N.; Shevchuk, I.;<br \/>\nChekulayev, V.; Kuznetsov, A. V.; Guzun, R.; Kaambre, T. (2014). <strong>The role of tubulin in the mitochondrial metabolism and arrangement in muscle cells.<\/strong> Journal of Bioenergetics and Biomembranes, 46, 421\u2212434.<\/p>\n<p>Anmann, Tiia; Varikmaa, Minna; Timohhina, Natalja; Tepp, Kersti; Shevchuk, Igor, Chekulayev, Vladimir&#8217;; Saks, Valdur; Kaambre, Tuuli. (2014). <strong>Formation of highly organized intracellular structure and energy metabolism in cardiac muscle cells during postnatal development of rat heart. <\/strong>Biochimica et Biophysica Acta (BBA) Bioenergetics, 1837 (8), 1350\u22121361. DOI: 10.1016\/j.bbabio.2014.03.015<\/p>\n<p>Kaldma, Andrus; Klepinin, Aleksandr; Chekulayev, Vladimir; Mado, Kati; Shevchuk, Igor; Timohhina, Natalja; Tepp, Kersti; Kandashvili, Manana; Varikmaa, Minna; Koit, Andre; Planken, Margus; Heck, Karoliina; Truu, Laura; Planken, Anu; Valvere, Vahur; Rebane, Egle; Kaambre, Tuuli. (2014). <strong>An in situ study of bioenergetic properties of human colorectal cancer: The regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome.<\/strong> The International Journal of Biochemistry &amp; Cell Biology, 55, 171\u2212186. DOI: 10.1016\/j.biocel.2014.09.004.<\/p>\n<p>Varikmaa, Minna; Bagur, Rafaela; K\u00e4\u00e4mbre, Tuuli; Grichine, Alexei; Timohhina,<br \/>\nNatalja; Tepp, Kersti; Shevchuk, Igor; Chekulayev, Vladimir; Metsis, Madis; Boucher, Francois; Saks, Valdur; Kuznetsov, Andrey V.; Guzun, Rita (2014). <strong>Role of mitochondria-cytoskeleton interactions in respiration regulation and mitochondrial organization in striated muscles.<\/strong> Biochimica et Biophysica Acta (BBA) Bioenergetics, 1837 (2), 232\u2212245. DOI: 10.1016\/j.bbabio.2013.10.011<\/p>\n<p>Klepinin, Aleksandr; Chekulayev, Vladimir; Timohhina, Natalja; Shevchuk, Igor;<br \/>\nTepp, Kersti; Kaldma, Andrus; Koit, Andre; Saks, Valdur; Kaambre, Tuuli (2014).<br \/>\n<strong>Comparative analysis of some aspects of mitochondrial metabolism in differentiated and undifferentiated neuroblastoma cells.<\/strong> Journal of Bioenergetics and Biomembranes, 46 (1), 17\u221231. DOI: 10.1007\/s10863-013-9529-5<\/p>\n<p>Saks, V.; Schlattner, U.;Tokarska-Schlattner, M.; Wallimann, T.; Bagur, R.; Zorman, S.; Pelosse, M.; Dos Santos, P.; Boucher, F; Kaambre, T.; Guzun, R. (2014). Systems Level Regulation of Cardiac Energy Fluxes Via Metabolic Cycles: Role of Creatine,Phosphotransfer Pathways, and AMPK Signaling. In: Aon, Miguel A.; Saks, Valdur; Schlattner, Uwe (Ed.). &#8221; SYSTEMS BIOLOGY OF METABOLIC AND SIGNALING NETWORKS: ENERGY, MASS AND INFORMATION TRANSFER.&#8221;. (261\u2212320). Heidelberg: Springer-Verlag Berlin. (Springer Series in Biophysics; 16). DOI: 10.1007\/978-3-642-38505-6_11<\/p>\n<h3>2013<\/h3>\n<p>Andre; Kaldma, Andrus; Guzun, Rita; Valvere, Vahur; Saks, Valdur (2013). <strong>Metabolic Control Analysis of Respiration in Human Cancer Tissue<\/strong>. Frontiers in Physiology, 4, 1\u22126. DOI: 10.3389\/fphys.2013.00151<\/p>\n<p>Varikmaa, M.; Guzun, R.; Grichine, A.; Gonzalez-Granillo, M;, Usson, Y.: Boucher,<br \/>\nF.; Kaambre, T.; Saks, V. (2013). Matters of the heart in bioenergetics: mitochondrial fusion into continuous reticulum is not needed for maximal respiratory activity. Journal of Bioenergetics and Biomembranes, 45 (4), 319\u2212331. DOI: 10.1007\/s10863-012 9494-4<\/p>\n<p>K\u00e4\u00e4mbre, Tuuli; Koit, Andre; \u0160evt\u0161uk, Igor; T\u0161ekulajev, Vladimir; Tepp, Kersti;<br \/>\nTimohhina, Natalja; Bogovskaja, Jelena; Valvere, Vahur; Saks, Valdur (2013). Uusi<br \/>\nsuundi kasvajate energiametabolismi uuringutes. Eesti Arst, 92 (5), 261\u2212267.<\/p>\n<p>Anmann, Tiia; Varikmaa, Minna; Tepp, Kersti; Timohhina, Natalja; \u0160evt\u0161uk, Igor;<br \/>\nT\u0161ekulajev, Vladimir; Saks, Valdur; K\u00e4\u00e4mbre, Tuuli (2013). S\u00fcdamerakkude<br \/>\ns\u00fcnnij\u00e4rgse arengu bioenergeetilised aspektid: struktuuri ja funktsiooni vaheliste seoste v\u00e4ljakujunemine. Eesti Arst, 92 (7), 372\u2212381<\/p>\n<p>K\u00e4\u00e4mbre, Tuuli; Varikmaa, Minna (2013). Energia, elu ja tervis: s\u00fcsteemibioloogiast, bioenergeetikast ja biomeditsiinist. Horisont, 1, 16\u221223.<br \/>\nKuznetsov, A.V.; Guzun, R.; Boucher, F.; Bagur, R.; K\u00e4\u00e4mbre, T.; Saks, V. (2012).<br \/>\nMysterious Ca2+-independent muscular contraction: deja vu. Biochemical Journal, 445, 333\u2212336. DOI: 10.1042\/BJ20120439.<\/p>\n<h3>2012<\/h3>\n<p>K\u00e4\u00e4mbre, T.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Timohhina, N.; Tepp, K.; Bogovskaja, J.; K\u00fctner, R.; Valvere, V.; Saks, V. (2012). <strong>Metabolic control <\/strong><strong>analysis of cellular respiration in situ in intraoperational samples of human breast <\/strong><strong>cancer.<\/strong> Journal of Bioenergetics and Biomembranes, 44 (5), 539\u2212558. DOI: 10.1007\/s10863-012-9457-9<\/p>\n<p>Guzun, R.; Gonzalez-Granillo, M.; Karu-Varikmaa, M.; Grichine, A.; Usson, Y.;<br \/>\nK\u00e4\u00e4mbre, T.; Guerrero-Roesch, K.; Kuznetsov, A.; Schlattner, U.; Saks, V. (2012).<br \/>\n<strong>Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial Interactosome.<\/strong> Biochimica et Biophysica Acta, 1818, 1545\u22121554. DOI: 10.1016\/j.bbamem.2011.12.034<br \/>\n.<br \/>\nGonzalez-Granillo, M.; Grichine, A.; Guzun, R.; Ussov, Y.; Tepp, K.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Kuznetsov, A.V.; Grimm, M.; Saks, V.; K\u00e4\u00e4mbre, T. (2012). <strong>Studies of the role of tubulin beta II isotype in regulation of mitochondrial respiration in intracellular energetic units in cardiac cells.<\/strong> Journal of Molecular and Cellular Cardiology, 52, 437\u2212447. DOI: 10.1016\/j.yjmcc.2011.07.027<\/p>\n<p>Saks, V.; Kuznetsov, A.V.; Gonzalez-Granillo, M.; Tepp, K.; Timohhina, N.; Karu<br \/>\nVarikmaa, M.; K\u00e4\u00e4mbre, T.; Santos, P.D.; Boucher, F.; Guzun, R. (2012). <strong>Intracellular energetic Units regulate metabolism in cardiac cells. Journal of Molecular and Cellular Cardiology<\/strong>, 419\u2212436. DOI: 10.1016\/j.yjmcc.2011.07.015<\/p>\n<h3>2011<\/h3>\n<p>Aliev, M., Guzun, R., Karu-Varikmaa, M., Kaambre, T., Wallimann, T., Saks, V.<br \/>\n(2011). <strong>Molecular system bioenergics of the heart: experimental studies of metabolic compartmentation and energy fluxes versus computer modeling.<\/strong> International Journal of Molecular Sciences, 12 (12), 9296\u22129331. DOI: 10.3390\/ijms12129296<\/p>\n<p>Tepp, Kersti; Shevchuk, Igor; Chekulayev, Vladimir; Timohhina, Natalja; Kuznetsov, Andrey V.; Guzun, Rita; Saks, Valdur; K\u00e4\u00e4mbre, Tuuli (2011). <strong>High efficiency of energy flux controls within mitochondrial interactosome in cardiac intracellular energetic units.<\/strong> Biochimica et Biophysica Acta (BBA) &#8211; Bioenergetics, 1807 (12), 1549\u22121561. DOI: 10.1016\/j.bbabio.2011.08.005.<\/p>\n<p>Guzun, R.; Timohhina, N.; Tepp, K.; Gonzalez-Granillo, M.; Shevchuk, I.;<br \/>\nChekulayev, V.; Kuznetsov, A.V.; K\u00e4\u00e4mbre, T.; Saks, V.A. (2011). <strong>Systems<\/strong><br \/>\n<strong>bioenergetics of creatine kinase networks: physiological roles of creatine and <\/strong><strong>phosphocreatine in regulation of cardiac cell function.<\/strong> Amino Acids, 40, 1333\u22121348.<\/p>\n<p>Guzun, Rita; Karu-Varikmaa, Minna; Gonzalez-Granillo, Marcela; Kuznetsov, Andrey V.; Michel, Lauriane; Cottet-Rousselle, Cecile; Saarem\u00e4e, Merle; K\u00e4\u00e4mbre, Tuuli; Metsis, Madis; Grimm, Michael; Auffray, Charles; Saks, Valdur (2011). <strong>Mitochondria cytoskeleton interaction: Distribution of beta-tubulins in cardiomyocytes and HL-1 cells.<\/strong> Biochimica et Biophysica Acta (BBA) &#8211; Bioenergetics, 1807 (4), 458\u2212469. DOI: 10.1016\/j.bbabio.2011.01.010<\/p>\n<p>Martma, K.; Habicht, K.-L.; Martinez Ramirez, X.; Tepp, K.; K\u00e4\u00e4mbre, T.;<br \/>\nVolobujeva, O.; Shimmo, R. (2011). <strong>Polydopamine as an adhesive coating for open <\/strong><strong>tubular capillary electrochromatography.<\/strong> Electrophoresis, 32 (9), 1054\u22121060. DOI:10.1002\/elps.201000569.<\/p>\n<p>Karu-Varikmaa, M.; Metsis, M.; Guzun, R.; K\u00e4\u00e4mbre, T.; Grichine, A.; Saks, V.<br \/>\n(2011). <strong>Investigation of interactions between mitochondrial creatine kinase and <\/strong><strong>ATP\/ADP channel.<\/strong> FEBS Journal, 278, 374\u2212375.<\/p>\n<p>Tepp, K.; Shevchuk, I.; Chekulayev, V.; Timohhina, N.; Saks, V.; K\u00e4\u00e4mbre, T. (2011). <strong>High efficiency of energy flux control with mitochondrial interactosome in cardiac cell.<\/strong> FEBS Journal, 278, 377\u2212377.<\/p>\n<p>Saks, V.; Aliev, M.; Tepp, K.; Karu-Varikmaa, M.; Chekulaev, V.; Shevchuk, I.;<br \/>\nK\u00e4\u00e4mbre, T.; Guzun, R. (2011). <strong>Quantitative Analysis of Integrated Energy<\/strong><br \/>\n<strong>Metabolism of Muscle Cells: Experimental and Theoretical Studies.<\/strong> Biophysical Journal, 100, 2a\u22122a.<\/p>\n<p>Gonzalez-Granillo, M.A.; Karu-Varikmaa, M.; Saarem\u00e4e, M.; Michel, L.; K\u00e4\u00e4mbre,<br \/>\nT.; Saks, V.; Guzun, R. (2011). <strong>Mitochondrial Interactosome in Energy Metabolism in Healthy and Cancer Cells.<\/strong> Biophysical Journal, 100, 298a\u2212298a.<\/p>\n<p>Karu-Varikmaa, M.; Saarem\u00e4e, M.; Sikk, P.; K\u00e4\u00e4mbre, T.; Metsis, M.; Saks, V.<br \/>\n(2011). <strong>Regulation of Mitochondrial Respiration by Different Tubulin Isoforms in <\/strong><strong>Vivo.<\/strong> Biophysical Journal, 100, 459a\u2212459a.<\/p>\n<h3>Earlier<\/h3>\n<p>Tepp, Kersti; Timohhina, Natalya; Chekulayev, Vladimir; Shevchuk, Igor; Kaambre, Tuuli; Saks, Valdur (2010). <strong>Metabolic control analysis of integrated energy metabolism in permeabilized cardiomyocytes &#8211; experimental study.<\/strong> Acta Biochimica Polonica, 57 (4), 421\u2212430.<\/p>\n<p>Saks, Valdur; Guzun, Rita; Timohhina, Natalja; Tepp, Kersti; Varikmaa, Minna;<br \/>\nMonge, Claire; Beraud, Nathalie; K\u00e4\u00e4mbre, Tuuli; Kuznetsov, Andrey; Kadaja,<br \/>\nLumme; Eimre, Margus; Seppet, Enn (2010). <strong>Structure-function relationships in <\/strong><strong>feedback regulation of energy fluxes in vivo in health and disease: Mitochondrial <\/strong><strong>Interactosome.<\/strong> Biochimica et Biophysica Acta, 1797 (6-7), 678\u2212697. DOI: 10.1016\/j.bbabio.2010.01.011.<\/p>\n<p>Guerrero, K.; Monge, C.; Br\u00fcckner, A.; Puurand, U.; Kadaja, L.; K\u00e4\u00e4mbre, T.; Seppet, E.; Saks, V. (2010). Study of possible interactions of tubulin, microtubular network, and STOP protein with mitochondria in muscle cells. Molecular and Cellular Biochemistry, 337, 239\u2212249. DOI: 10.1007\/s11010-009-0304-1<br \/>\nMonge, Claire; Guzun, Rita; Tepp, Kersti; Timohhina, Natalja; Varikmaa, Minna;<br \/>\nSikk, Peeter; K\u00e4\u00e4mbre, Tuuli; Saks, Valdur (2010). <strong>Mitochondrial Interactosome in <\/strong><strong>Health and Disease: Structural and Functional Aspects of Molecular System <\/strong><strong>Bioenergetics of Muscle and Neuronal Cells.<\/strong> In: Oliver L. Svensson (Ed.). Mitochondria: Structure, Functions and Dysfunctions. (441\u2212470). Nova Science Publisher Inc..<\/p>\n<p>Varikmaa, Minna; Metsis, Madis; Guzun, Rita; K\u00e4\u00e4mbre, Tuuli; Grichine, Alexei;<br \/>\nSaks, Valdur (2010). <strong>Novel Method for Investigation of Interactions between <\/strong><strong>Mitochondrial Creatine Kinase and Adenine Nucleotide Translocase.<\/strong> Biophysical Journal, 98: Biophysical Society 54th Annual Meeting, February 20-24 , San Fransisco. 2010, 735a. (3).<\/p>\n<p>Timohhina, Natalja; Guzun, Rita; Tepp, Kersti; Monge, Claire; Varikmaa, Minna; Vija, Heiki; Sikk, Peeter; K\u00e4\u00e4mbre, Tuuli; Sackett, Dan; Saks, Valdur (2009). <strong>Direct measurement of energy fluxes from mitochondria into cytoplasm in permeabilized cardiac cells in situ: some evidence for mitochondrial interactosome.<\/strong> Journal of Bioenergetics and Biomembranes, 41 (3), 259\u2212275.<\/p>\n<p>Guzun, R.; Timohhina, N.; Tepp, K.; Monge, C.; K\u00e4\u00e4mbre, T.; Sikk, P.; Kuznetsov,<br \/>\nAV.; Pison, C.; Saks, V. (2009). <strong>Regulation of respiration controlled by mitochondrial creatine kinase in permeabilized cardiac cells in situ importance of system level properties.<\/strong> Biochimica et Biophysica Acta (BBA) &#8211; Bioenergetics, 1787 (9), 1089\u22121105. DOI: 10.1016\/j.bbabio.2009.03.024.<\/p>\n<p>Monge, Claire; Beraud, Nathalie; Tepp, Kersti; Pelloux, Sophie; Chahboun, Siham;<br \/>\nK\u00e4\u00e4mbre, Tuuli; Kadaja, Lumme; Roosimaa, Mart; Piirsoo, Andres; Tourneur, Yves; Kuznetsov, Andrey V; Saks, Valdur; Seppet, Enn (2009). <strong>Comparative analysis of the bioenergetics of adult cardiomyocytes and nonbeating HL-1 cells: respiratory chain activities, glycolytic enzyme profiles, and metabolic fluxes.<\/strong> Canadian Journal of Physiology and Pharmacology, 87 (4), 318\u2212326.<\/p>\n<p>Sikk, Peeter; K\u00e4\u00e4mbre, Tuuli; Vija, Heiki; Tepp, Kersti; Tiivel, Toomas; Nutt, Anu;<br \/>\nSaks, Valdur (2009). <strong>Ultra performance liquid chromatography analysis of adenine <\/strong><strong>nucleotides and creatine derivatives for kinetic studies.<\/strong> Proceedings of the Estonian Academy of Sciences, 58 (2), 122\u2212131.<\/p>\n<p>Sepp, Mervi; Kaambre, Tuuli; Sikk, Peeter; Vendelin, Marko; Birkedal, Rikke (2009). <strong>Kinetic studies of intracellular compartmentalization in permeabilized rat <\/strong><strong>cardiomyocytes.<\/strong> The Journal of Physiological Sciences, 59, 362.<\/p>\n<p>K\u00e4\u00e4mbre, Tuuli; Sikk, Peeter; Anmann, Tiia; Tiivel, Toomas; Timohhina, Natalja;<br \/>\nNutt, Anu; Tepp, Kersti; Saks, Valdur (2008).<strong> S\u00fcdamelihase rakkude struktuuri <\/strong><strong>olulisusest rakuhingamise regulatsioonis.<\/strong> Eesti Arst, 1, 19\u221222.<\/p>\n<p>Saks, V.; Kaambre, T.; Guzun, R.; Anmann, T.; Sikk, P.; Schlattner, U.; Wallimann,<br \/>\nT.; Aliev, M.; Vendelin, M. (2007). <strong>The creatine kinase phosphotransfer network: <\/strong><strong>thermodynamic and kinetic considerations, the impact of the mitochondrial outer <\/strong><strong>membrane and modelling approaches.<\/strong> In: Salomons, G.S.; Wyss, M. (Ed.). Creatine and Creatine Kinase in Health and Disease. (27\u221265). Dordrecht: Springer. (Subcellular Biochemistry; 46). DOI: 10.1007\/978-1-4020-6486-9_3.<\/p>\n<p>Anmann, T.; Guzun, R.; Beraud, N.; Pelloux, S.; Kuznetsov, A.V.; Kogerman, L.;<br \/>\nKaambre, T.; Sikk, P.; Paju, K.; Peet, N.; Seppet, E.; Ojeda, C.; Tourneur, Y.; Saks, V. (2006). <strong>Different kinetics of the regulation of respiration in permeabilized <\/strong><strong>cardiomyocytes and in HL-1 cardiac cells &#8211; Importance of cell structure\/organization for respiration regulation.<\/strong> Biochimica et Biophysica Acta (BBA) &#8211; Bioenergetics, 1757 (12), 1597\u22121606 . DOI: 10.1016\/j.bbabio.2006.09.008<br \/>\n.<br \/>\nSeppet, E.K.; Eimre, M.; Anmann, T.; Seppet, E.; Piirsoo, A.; Peet, N.; Paju, K.;<br \/>\nGuzun, R.; Beraud, N.; Pelloux, S.; Tourneur, Y.; Kuznetsov, A.V.; K\u00e4\u00e4mbre, T.; Sikk, P.; Saks, V.A. (2006). <strong>Structure-function relationships in regulation of the energy transfer between mitochondria and ATPases in cardiac cells. Experimental and Clinical Cardiology<\/strong>, 11 (3), 189\u2212194.<\/p>\n<p>Seppet, E.K.; Eimre, M.; Paju, K.; Orlova, E.; Piirsoo, A.; Sikk, P.; Kaambre, T.; Saks, VA. (2006). <strong>Calcium-induced contraction of sarcomeres changes the interaction between mitochondria and ATPases in permeabilized cardiac cells.<\/strong> Journal of Molecular and Cellular Cardiology, 40 (6), 931\u2212931.<\/p>\n<p>Eimre, M.; Seppet, E.; Paju, K.; Orlova, E.; Piirsoo, A.; Sikk, P.; K\u00e4\u00e4mbre, T.; Saks,<br \/>\nV. (2006). <strong>Kaltsiumist p\u00f5hjustatud sarkomeeride kontraktsioon muudab mitokondrite ja ATPaaside vahelist interaktsiooni permeabiliseeritud s\u00fcdamerakkudes.<\/strong> 85. , 645\u2212646.<\/p>\n<p>Anmann, T.; Eimre, M.; Kuznetsov, AV.; Andrienko, T.; Kaambre, T.; Sikk, P.;<br \/>\nSeppet, E.; Tiivel, T.; Vendelin, M.; Seppet, E.; Saks, VA. (2005). <strong>Calcium-induced <\/strong><strong>contraction of sarcomeres changes the regulation of mitochondrial respiration in <\/strong><strong>permeabilized cardiac cells.<\/strong> FEBS Journal, 272 (12), 3145\u22123161. DOI:10.1111\/j.1742-4658.2005.04734.x.<\/p>\n<p>Seppet, E. K.; Eimre, M.; Anmann, T.; Seppet, E.; Peet, N.; K\u00e4\u00e4mbre, T.; Paju, K.;<br \/>\nPiirsoo, A.; Kuznetsov, A. V.; Vendelin, M.; Gellerich, F. N.; Zierz, S.; Saks, V. A.<br \/>\n(2005). <strong>Intracellular energetic units in healthy and diseased hearts.<\/strong> Experimental and Clinical Cardiology, 10 (3), 173\u2212183.<\/p>\n<p>Seppet, EK.; Eimre, M.; Kaambre, T.; Piirsoo, A. (2005). Compartmentation of energy metabolism in heart cells: Structure-function relationships. JOURNAL OF<br \/>\nMOLECULAR AND CELLULAR CARDIOLOGY, 38. , 1065\u22121066.<\/p>\n<p>Seppet, EK.; Eimre, M.; Andrienko, T.; Kaambre, T.; Sikk, P.; Kuznetsov, AV.; Saks,V. (2004). <strong>Studies of mitochondrial respiration in muscle cells in situ: Use and misuse of experimental evidence in mathematical modelling.<\/strong> Molecular and Cellular Biochemistry, 256, 219\u2212227.<\/p>\n<p>Saks, V.; Andrienko, T.; Kuznetsov, A.; Zorov, D; K\u00e4\u00e4mbre, T.; Sikk, P. (2004). <strong>Ca2+ contraction and mitochondria in heart: A mechanochemical link?<\/strong> 86. , 336A\u2212337A.<\/p>\n<p>Andrienko, T.; Kuznetsov, A.V.;Kaambre, T.; Usson, Y.; Orosco, A.; Appaix, F.;<br \/>\nTiivel, T.; Sikk, P.; Vendelin, M.; Margreiter, R.; Saks, V.A. (2003). <strong>Metabolic<\/strong><br \/>\n<strong>consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cells.<\/strong> Journal of Experimental Biology, 206 (12), 2059\u22122072.<\/p>\n<p>Saks, Valdur; Kuznetsov, Andrey; Andrienko, Tatiana; Usson, Yves; Appaix,<br \/>\nFlorence; Guerrero, Karen; Kaambre, Tuuli; Sikk, Peeter; Lemba, Maris; Vendelin,<br \/>\nMarko (2003). <strong>Heterogeneity of ADP diffusion and regulation of respiration in cardiac cells.<\/strong> Biophysical Journal, 84 (5), 3436\u22123456. DOI: 10.1016\/S0006-3495(03)70065-4.<\/p>\n<p>Appaix, F.; Kuznetsov, A. V.; Usson, Y.; Kay, L.; Andrienko, T.; Olivares, J.;<br \/>\nKaambre, T.; Sikk, P.; Margreiter, R.; Saks, V. (2003). <strong>Possible role of cytoskeleton in intracellular arrangement and regulation of mitochondria.<\/strong> Experimental Physiology, 88, 175\u2212190. DOI: 10.1113\/eph8802511<\/p>\n<p>Appaix, F.; Guerrero, K.; Rampal, D.; Izikki, M.; Kaambre, T.; Sikk, P.; Brdiczka, D.; Riva-Lavieille, C.; Olivares, J.; Longuet, M.; Antonsson, B.; Saks, V. (2002). <strong>Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition.<\/strong> Biochimica et Biophysica Acta, 1556, 156\u2212167.<\/p>\n<p>Seppet, EK.; Kadaja, L.; Braun, U.; Kisand, K.; Metskula, K.; Uibo, R.; Kaambre, T.; Valdur, A. (2002). <strong>Intracellular energetic units in cardiac cells: Targets in primary biliary cirrhosis.<\/strong> Journal of Molecular and Cellular Cardiology, 34 (6), A57\u2212A57.<\/p>\n<p>Seppet, EK.; Kaambre, T.; Sikk, P.; Tiivel, T.; Vija, H.; Tonkonogi, M.; Sahlin, K.;<br \/>\nKay, L.; Appaix, F.; Braun, U.; Eimre, M.; Saks, VA. (2001). <strong>Functional complexes of mitochondria with Ca,MgATPases of myofibrils and sarcoplasmic reticulum in muscle cells.<\/strong> Biochimica et Biophysica Acta (BBA) &#8211; Bioenergetics, 1504, 379\u2212395. DOI: 10.1016\/S0005-2728(00)00269-3.<\/p>\n<p>Saks, VA.; Kaambre, T.; Sikk, P.; Eimre, M.; Orlova, E.; Paju, K.; Piirsoo, A.; Appaix, F.; Kay, L.; Regitz-Zagrosek, V.; Fleck, E.; Seppet, E. (2001). <strong>Intracellular energetic units in red muscle cells<\/strong>. Biochemical Journal, 356, 643\u2212657.<\/p>\n<p>Saks, V.; Kay, L.; Sikk, P.; Kaambre, T.; Seppet, E.; Piirsoo, A. (2001). <strong>Intracellular <\/strong><strong>energetic units in muscle cells?<\/strong> Biophysical Journal, 80 (1), 583A\u2212583A.<\/p>\n<p>Tiivel, T.; Kadaya, L.; Kuznetsov, A.; Kaambre, T.; Peet, N.; Sikk, P.; Braun, U.;<br \/>\nVentura-Clapier, R.; Saks, V.; Seppet, EK. (2000). <strong>Developmental changes in<\/strong><br \/>\n<strong>regulation of mitochondrial respiration by ADP and creatine in rat heart in vivo. <\/strong>Molecular and Cellular Biochemistry, 208, 119\u2212128.<\/p>\n<p>Saks, VA.; Tiivel, T.; Sikk, P.; Kaambre, T.; Kay, L.; Tonkonogi, M.; Seppet, E.;<br \/>\nSahlin, K. (2000). <strong>Metabolic channelling in cardiac cells: Dependence of kinetics of <\/strong><strong>respiration regulation on source of ADP.<\/strong> Biophysical Journal, 78 (1), 197A\u2212197A.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/section>\n<section class=\"publications_load\"><script>\n$(window).on(\"load\", function (){\n$(\"#publications_current\").load(\"https:\/\/kbfi.ee\/kb\/teadustoo\/2021-2\/ #p2021\");\n})\n<\/script><br \/>\n<script>\n$(\"div.timeline_content\").on(\"click\", function(e) {\n$(\"#publications_current\").load(\"https:\/\/kbfi.ee\/kb\/teadustoo\/\" + e.target.id + \"-2\/ #p\" + e.target.id);\n})\n<\/script><\/p>\n<\/section>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a02021 &#8211; 2020 &#8211; 2019 &#8211; 2018 &#8211;\u00a02017 &#8211;\u00a02016 &#8211;\u00a02015 &#8211;\u00a02014 &#8211;\u00a02013 &#8211;\u00a02012 &#8211;\u00a02011 &#8211; 2010 &#8211; 2009 Earlie \u00a02025 Marju <a class=\"read-more\" href=\"https:\/\/kbfi.ee\/en\/cb\/research\/publications\/\"><\/a><\/p>\n","protected":false},"author":33,"featured_media":0,"parent":1382,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"tpl-flexible.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3078","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/pages\/3078"}],"collection":[{"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/users\/33"}],"replies":[{"embeddable":true,"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/comments?post=3078"}],"version-history":[{"count":0,"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/pages\/3078\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/pages\/1382"}],"wp:attachment":[{"href":"https:\/\/kbfi.ee\/en\/wp-json\/wp\/v2\/media?parent=3078"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}