Vanemad

2010

1. Guerroro K., Monge C., Bruckner A., Puurand U., Kadaja L., Kaambre T., Seppet E., Saks V.

   Study of possible interactions of tubulin, microtubular networks and STOP protein with mitochondria in muscle cells. Mol. Cell Biochem (2010), 37:239-249.

2. Guzun R., Saks V.

   Application of the principles of systems biology and Wiener’s cybernetics for analysis of regulation of energy fluxes in muscle cells in vivo. Int.J.Mol.Sci. (2010), 11:982-1019.

3. Saks V., Guzun R., Timohhina N., Tepp K., Vaarikmaa M., Monge C., Beraud N., Kaambre T., Kuznetsov A., Kadaja L., Eimre M., Seppet E.

   Structure-function relationships in feedback regulation of energy fluxes in vivo in health and disease: Mitochondrial Interactosome. Biochim. Biophys. Acta (2010), 1797: 678-697.

4. Monge C., Guzun R., Tepp K., Timohhina N., Varikmaa M., Sikk P., Kaambre T., Saks V.

   Mitochondrial Interactosome in Health and Disease: Structural and Functional Aspects of Molecular System Bioenergetics of Muscle and Neuronal Cells. In: Mitochondria: Structure, Functions and Dysfunctions. (2010), Ed. Oliver L. Svensson, Nova Science Publishers, Inc.

5. Tepp K., Timohhina N., Chekulayev V., Shevchuk I., Kaambre T., Saks, V.

   etabolic control analysis of integrated energy metabolism in permeabilized cardiomyocytes. Acta Biochimica Polonica (2010), 57(4), 421-430.

6. Tokarska-Schlattner M., Lucchinetti E., Zaugg M., Kay L., Gratia S., Guzun R., Saks V., Schlattner U.

   Early effects of doxorubicin in perfused heart: transcriptional profiling reveals inhibition of cellular stress response genes. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2010), Apr;298:R1075-88.

7. Varikmaa M., Metsis M., Guzun R., Käämbre T., Grichine A., Saks V.

   Novel Method for Investigation of Interactions between Mitochondrial Creatine Kinase and Adenine Nucleotide Translocase. Biophysical Journal (2010), 98; 3, 735a.

8. Tepp K., Timohhina N., Chekulayev V., Shevchuk I., Kaambre T., Saks, V.

   Metabolic control analysis of integrated energy metabolism in permeabilized cardiomyocytes. Biochim. Biophys Acta, Bioenergetics (2010), EBEC abstract book 1797: 138-139.

9. Saks V., Guzun R., Timohhina N., Tepp K., Vaarikmaa M., Monge C., Beraud N., Kaambre T., Kuznetsov A., Kadaja L., Eimre M., Seppet E.

   Biochim. Biophys. (2010), Acta EBEC abstract book 1797: 138.

2009

1. Beraud N., Pelloux S., Usson Y., Kuznetsov AV., Ronot X., Tourneur Y., Saks V.

   Mitochondrial dynamics in heart cells: very low amplitude high frequency fluctuations in adult cardiomyocytes and flow motion in non beating Hl-1 cells. J.Bioenerg.Biomembr. (2009), Apr;41(2):195-214.

2. Timohhina N., Guzun R., Tepp K., Monge C., Varikmaa M., Vija H., Sikk P., Kaambre T., Sackett D., Saks V.

   Direct measurement of energy fluxes from mitochondria into cytoplasm in permeabilized cardiac cells in situ: some evidence for Mitochondrial Interactosome. Bioenerg.Biomembr. (2009), Jun;41(3):259-75.

3. Saks V., Monge C., Guzun R.

   Philosophical basis and some historical aspects of systems biology: from Hegel to Noble – applications for bioenergetic research. Int.J.Mol.Sci. (2009), Mar;10(3):1161-92.

4. Monge C., Beraud N., Tepp K., Pelloux S., Chahboun S., Kaambre T., Kadaja L., Roosimaa M., Piirsoo A., Tourneur Y., Kuznetsov AV., Saks V., Seppet E.

   Comparative analysis of the bioenergetics of adult cardiomyocyte s and nonbeating HL-1 cells: respiratory chain activities, glycolytic enzyme profiles, and metabolic fluxes. Can.J.Physiol.Pharmacol. (2009), Apr;87(4):318-26.

5. Guzun R., Timohhina N., Tepp K., Monge C., Kaambre T., Sikk P., Kuznetsov AV., Pison C., Saks V.

   Regulation of respiration controlled by mitochondrial creatine kinase in permeabilized cardiac cells in situ. Importance of system level properties. Biochim. Biophys. Acta (2009), Sep;1787(9):1089-105.

6. Saks V.

   Molecular System Bioenergetics-New Aspects of Metabolic Research. Intern. J.Mol. Sci. (2009), vol10:8:3655-3657.

7. Sikk P., Kaambre T., Vija H., Tepp K., Tiivel T., Nutt A., Saks V.

   Ultra performance liquid chromatography analysis of adenine nucleotides and creatine derivatives for kinetic studies.Proceedings of the Estonian Academy of Sciences (2009), Vol: 58:2 122-131.

8. Sepp M., Kaambre T., Sikk P., Vendelin M., Birkedal R.

   Kinetic studies of intracellular compartmentalization in permeabilized rat cardiomyocytes. Biophysical Journal (2009), 96 (3, Supplement 1), 241a – 242a.

9. Sepp M., Kaambre., T, Sikk P., Vendelin M., Birkedal R.

   Kinetic studies of intracellular compartmentalization in permeabilized rat cardiomyocytes. In: 36th International Congress of Physiological Sciences (2009), July 27-August 1, Kyoto, Japan.

10. Kuznetsov AV., Hermann M., Saks V., Hengster P., Margreiter R.

    The cell-type specificity of mitochondrial dynamics. Int J Biochem Cell Biol (2009), 41: 1928-39.

2008

1. Eimre M., Paju K., Pelloux S., Beraud N., Roosimaa M., Kadaja L., Gruno M., Peet N., Orlova E., Remmelkoor R., Piirsoo A., Saks V., Seppet E.

   Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes. Biochimica et Biophysica Acta (BBA) – Bioenergetics (2008), 1777, 514 – 524.

2. Kuznetsov, AV., Veksler V., Gellerich FN., Saks V., Margreiter R., Kunz WS.

   Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells. Nature Protocols (2008), 3, 965-976

3. Saks V.

   The phosphocreatine-creatine kinase system helps to shape muscle cells and keep them healthy and alive. Journal of Physiology (2008),586, 2817 – 2818.

4. Monge C., Beraud N., Kuznetsov AV., Rostovtseva T., Sackett D., Schlattner U., Vendelin M., Saks V..

   Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion in situ, roles of tubulin, and mitochondrial creatine kinase. Molecular and Cellular Biochemistry (2008), 318(1-2):147-65.

5. Saks V., Beraud N., Wallimann T.

   Metabolic compartmentation – A system level property of muscle cells. International Journal of Molecular Sciences (2008), 9, 751 – 767.

6. Käämbre T., Sikk P., Anmann T., Tiivel T., Timohhina N., Nutt A., Tepp K., Saks V.

   Südamelihase rakkude struktuuri olulisusest rakuhingamise regulatsioonis. Eesti Arst (2008), 19 – 22.

7. Guzun, R., Timohhina N., Käämbre T., Sikk P., Anmann T., Saks V.

   Different steady state kinetics of regulation of MtCK-dependent respiration in isolated mitochondria and permeabilized cardiac cell in situ. Biophysical Society 52nd Annual Meeting & 16th International Biophysics Congress (2008), February 2-6, Long Beach, California.

8. Seppet E., Paju K., Roosimaa M., Kadaja L., Peet N., Eimre M., Orlova E., Saks V.

   Distinct organization of energy metabolism in different types of cardiac cells. NATO Advanced Research Workshop on Translational Knowledge for Heart Research (2008), Istanbul, Turkey; 12-16 May.

9. Seppet E., Paju K., Roosimaa M., Kadaja L., Peet N., Eimre M., Orlova E., Saks V.

   Distinct organization of energy metabolism in HL-1 cardiac cells and cardiomyocytes. Journal of Molecular and Cellular Cardiology (2008), 44, 780 – 781.

10. Saks V., Engelbrecht J., Seppet E., Vendelin M.

    Teaduspreemia geo-ja bioteaduste alal tööde tsükli “Molekulaarne süsteemne bioenergeetika” eest. Villems,Richard (Eds.). Eesti Vabariigi teaduspreemiad (2008),(110 – 123). Tallinn: Eesti Teaduste Akadeemia.

2007

1. Saks V., Vendelin M., Aliev M., Kekelidze T., Engelbrecht J.

   Mechanisms and modeling of energy transfer between and among intracellular compartments. In: /Handbook of Neurochemistry and Molecular Neurobiology, 3edition/, volume 5, /Brain Energetics, / Dienel G. and Gibson G. (Editors), Springer Science, New York, (2007), 815-860.

2. Saks V. (Editor)

   “Molecular System Bioenergetics. Energy for life”. (2007),Wiley-VCH, Manheim.

3. Saks V., Anmann T., Guzun R., Käämbre T., Sikk P., Schlattner U., Wallimann T., Aliev M., Vendelin M.

   The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approaches. In Subcellular Biochemistry (2007), vol. 46, “Creatine and Creatine Kinase in Health and Disease”, Wyss M., Salomons G. (Eds), Springer, Dordrecht, The Netherlands.

4. Saks V., Monge C., Anmann T., Dzeja P.

   Integrated and organized cellular energetic systems: theories of cell energetics, compartmentation and metabolic channeling. In: “Molecular System Bioenergetics. Energy for life”. (2007),Wiley -VCH, Manheim.

5. Saks V., Dzeja P., Guzun R., Aliev M., Vendelin M., Terzic A., Wallimann T.

   System analysis of cardiac energetics – excitation-contraction coupling: integration of mitochondrial respiration, phosphotransfer pathways, metabolic pacing and substrate supply in the heart. In: “Molecular System Bioenergetics. Energy for life” (2007), Wiley -VCH, Manheim.

6. Vendelin M.,Saks V., Engelbrecht J.

   Principles of mathematical modeling and /in silico/ studies of integrated systems of cellular energetics. In:“Molecular System Bioenergetics. Energy for life” (2007), Wiley -VCH, Manheim.

7. Saks V.

   From the discovery of oxygen to molecular system bioenergetics. In:“Molecular System Bioenergetics. Energy for life” (2007), Wiley -VCH, Manheim.

2006

1. Beraud N., Pelloux,S., Kuznetsov,A., Guzun R., Anmann T., Tourneur Y., Ojeda C., Saks V.

   Comparative bioeneregetics of isolated cardiomyocytes and HL-1 cells: Mitochondrial dynamics, respiration regulation and creatine kinase expression. Biochim. Biophys. Acta-Bioenergetics, (Suppl.S) (2006), 514 – 515.

2. Eimre M., Seppet E., Paju K., Orlova E., Piirsoo A.; Sikk P., Käämbre, T., Saks, V.

   Kaltsiumist põhjustatud sarkomeeride kontraktsioon muudab mitokondrite ja ATPaaside vahelist interaktsiooni permeabiliseeritud südamerakkudes. Eesti Arst (2006), (9): 645 – 646.

3. Anmann T., Guzun R., Beraud N., Pelloux S., Kuznetsov A.V., Kogerman L.,Käämbre T., Sikk, P., Paju K., Peet N., Seppet E., Ojeda C., Tourneur Y., Saks V.

   Different kinetics of the regulation of respiration in permeabilized cardiomyocytes and in HL-1 cardiac cells. Biochim. Biophys. Acta-Bioenergetics (2006), (12) 1757: 1597-1606.

4. Saks V., Aliev M., Guzun R., Beraud N., Monge C., Anmann T., Kuznetsov A., Seppet E.

   Biophysics of the organized metabolic networks in muscle and brain cells. Recent Res. Devel. Biophys (2006), (5) 269-318. Kerala, India: Transworld Research Networks.

5. Seppet E.K., Eimre M., Anmann T., Seppet E., Piirsoo A., Peet N., Paju K., Guzun R., Beraud N., Pelloux S., Tourneur Y., Kuznetsov AV., Käämbre T., Sikk, P., Saks V.

   Structure-function relationships in regulation of the energy transfer between mitochondria and ATPases in cardiac cells. Exp. Clin. Cardiol. (2006), 11(3): 189 – 194.

6. Saks V., Dzeja P., Schlattner U., Vendelin M., Terzic A., Wallimann T.

   Cardiac system bioenergetics: metabolic basis of the Frank-Starling law. J. Physiol (2006), 571(2): 253 – 273.

7. Saks V., Favier R., Guzun R., Schlattner U., Wallimann T.

   Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands. J. Physiol (2006), 577(Pt 3):769-77.

8. Eimre M., Puhke R., Alev K., Seppet E., Sikkut A., Peet N., Kadaja L., Lenzner A., Haviko T., Seene T., Saks V.

   Altered mitochondrial Altered mitochondrial apparent affinity for ADP and impaired function of mitochondrial creatine kinase in gluteus medius of patients with hip osteoarthritis. Am. J. Physiol. Regul. Integr. Comp. Physiol (2006), 290:R1271-5.

2005

1. Vendelin, M., Beraud, M., Guerrero, K., Andrienko, T., Kuznetsov A. V., Olivares J., Kay L., Saks V.A. (2005). Mitochondrial regular arrangement in muscle cells: a “crystal-like” pattern. Am. J. Physiol. Cell. Physiol. 288 (3): C757-C767.
2. Seppet, E., Eimre, M., Peet, N., Paju, K., Orlova, E., Ress, M., Kovask, S., Piirsoo, A., Saks, V. A., Gellerich, F. N., Zierz, S., Seppet, E. K. (2005). Compartmentation of energy metabolism in atrial myocardium of patients undergoing cardiac surgery. Mol. Cell. Biochem. 270(1-2): 49-61.
3. Saks, V., Guerrero, K., Vendelin, M., Engelbrecht, J. Seppet E. (2005). The creatine kinase isoenzymes in organized metabolic networks and regulation of cellular respiration: a new role for Maxwell’s demon. In: Creatine Kinase (Vial C., Ed.) in series: Molecular Anatomy and Physiology of Proteins (Uversky V.N., series Ed.), NovaScience Publishers, New York.
4. Saks, V.A., Vendelin, M., Aliev M.K. Kekelidze, T. and  Engelbrecht, J. (2005). Mechanisms and modeling of energy transfer between and among intracellular compartments. In: Handbook of Neurochemistry and Molecular Neurobiology, 3edition, volume 5, Neural Energy Utilization,  Dienel G. and Gibson G., the Editors, Springer Science + Business Media, New York-Boston.
5. Anmann, T., Eimre, M, Kuznetsov, A.V., Andrienko, T.,  Käämbre, T., Sikk, P., Seppet, E., Tiivel, T., Vendelin, M., Seppet, E., Saks V.A. (2005). Calcium-induced contraction of sarcomeres changes regulation of mitochondrial respiration in permeabilized cardiac cells. FEBS Journal 272 (12): 3145-3161.
6. Seppet, E. K., Eimre, M., Anmann, T., Seppet E., Peet N., Käämbre, T., Paju K., Piirsoo, A., Kuznetsov, A. V., Vendelin, M., Gellerich, F: N., Zierz S., Saks V. A., (2005). Intracellular energetic units in healthy and diseased hearts. Exp. Clin. Cardiol. 10(3): 173-183.

2005

1. Varikmaa M., Bagur R., Kaambre T., Grichine A., Timohhina N., Tepp K., Shevchuk I., Chekulayev V., Metsis M., Boucher F., Kuznetsov A.V., Guzun R. (2014). Role of mitochondria-cytoskeleton interactions in respiration regulation and mitochondrial organization in striated muscles. Biochim Biophys Acta. 1837(2):232-45.
2. Klepinin A., Chekulayev V., Timohhina N., Shevchuk I., Tepp K., Kaldma A., Koit A., Saks V., Kaambre T. (2013). Comparative analysis of some aspects of mitochondrial metabolism in differentiated and undifferentiated neuroblastoma cells. J. Bioenerg. Biomembr. 46(1):17-31.
3. Anmann T., Varikmaa M., Timohhina N., Tepp K., Shevchuk I., Chekulayev V., Saks V., Käämbre T. (2014). Formation of highly organized intracellular structure and metabolism in cardiac muscle cells during postnatal development of rat heart. Biochim Biophys Acta. doi: 10.1016/j.bbabio.2014.03.015.
4. Guzun R., Kaambre T., Bagur R., Grichine A., Usson Y., Varikmaa M., Anmann T., Tepp K., Timohhina N., Shevchuk I., Chekulayev V., Boucher F., Schlattner U., Wallimann T., Kuznetsov, AV., Dzeja P., Aliev M., Saks V. (2014). Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation. Acta Physiologica. doi: 10.1111/apha.12287.
5. Timohhina N., Tepp K., Klepinin A., Mado K., Chekulayev V., Shevchuk I., Kaambre T. (2014). Age-related changes in the cardiac cell functioning. Biochim Biophys Acta. 1837, e128.
6. Klepinin A., Kaldma A., Chekulayev V., Mado K., Shevchuk I.,  Timohhina N., Tepp K.,  Kandashvili M., Koit A., Heck K., Truu L., Planken A., Kaambre T.(2014). Studies of the role of CK and AK energy transfer pathway in human colorectal cancer. Biochim. Biophys. Acta. 1837, e65.
7. Shevchuk I., Kaldma A., Koit A., Chekulayev V., Timohhina N., Tepp K., Mado K., Kandashvili M., Heck K., Truu L., Planken A., Kaambre T. (2014). Bioenergetic profiling of human colorectal cancer clinical material. Biochim. Biophys. Acta. 1837, e129.
8. Kaldma A., Klepinin A., Chekulayev V., Mado K., Shevchuk I., Timohhina N., Tepp K., Kandashvili M.,  Varikmaa M., Koit A., Planken M., Heck K., Truu L., Planken A., Kaambre T. (2014) An in situ study of bioenergetic properties of human colorectal cancer: the regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome. Int. J. Biochem. Cell Biol.
9. Tepp K., Mado K., Varikmaa M., Klepinin A., Timohhina N., Shevchuk I., Chekulayev V., Kuznetsov A.V., Guzun R.,  Kaambre T. (2014). The role of tubulin in the mitochondrial metabolism and arrangement in muscle cells. J. Bioener. Biomembr.
10. Systems Biology of Metabolic and Signalling Networks: Energy, Mass and Information Transfer. M. Aon., V. Saks., U. Schlattner (Editors) (2014). Book series: Springer Series in Biophysics. Vol. 16, 375 p. SPRINGER-VERLAG BERLIN, Germany.
11. M. Aon, D. Lloyd,  V. Saks. (2014). From Physiology, Genomes, Systems, and self-Organization to Systems Biology: The Historical Roots of a Twenty-First Century Approach to Complexity. In: Systems Biology of Metabolic and Signalling Networks: Energy, Mass and Information Transfer. Vol.16, pp 3-17. Eds: M. Aon., V. Saks., U. Schlattner. SPRINGER-VERLAG BERLIN, Germany.
12. Saks V., Schlattner U., Tokarska-Schlattner M., Wallimann T., Bagur R., Zorman S., Pelosse M., Dos Santos P., Boucher F., Kaambre T., Guzun R. (2014). Systems level regulation of cardiac energy fluxes via metabolic cycles: role of creatine, phosphotransfer pathways, and AMPK signaling. In: Systems Biology of Metabolic and signaling Networks: Energy, Mass and Information Transfer. Vol.16, pp 261-320. Eds. Aon MA., Saks V., Schlattner U. SPRINGER-VERLAG BERLIN, Germany.